Signaling lymphocytic activation molecule

UniProt data

UniProt name: SLAF1_HUMAN (Q13291)

Gene name: SLAMF1; Synonyms=SLAM

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for measles virus; also including isoform 4 (PubMed:10972291, PubMed:25710480). Involved in innate immune response against Gram- negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396). {ECO:0000269|PubMed:10972291, ECO:0000269|PubMed:20818396}.

Subcellular location: Isoform 4: Cell membrane {ECO:0000305|PubMed:25710480}. Note=Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers. {ECO:0000269|PubMed:25710480}.

Transmembrane domains:

  1. 238-258, 21 AA, Helical. {ECO:0000255}.

Sequence: 335 AA

10 20 30 40 50 60 MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE RINKSMNKSI 70 80 90 100 110 120 HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL ENLTLGIRES RKEDEGWYLM 130 140 150 160 170 180 TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN KTQENGTCTL ILGCTVEKGD HVAYSWSEKA 190 200 210 220 230 240 GTHPLNPANS SHLLSLTLGP QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV 250 260 270 280 290 300 YAGLLGGVIM ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ 310 320 330 DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES

CATM prediction

The sequence of SLAF1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       240       250       26
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TKAWAVYAGLLGGVIMILIMVVILQLR 6.8 -45.2° 4.0 39.1 -33.7
Model 2 TKAWAVYAGLLGGVIMILIMVVILQLR 7.0 -46.1° 2.7 47.1 -27.3
Model 3 TKAWAVYAGLLGGVIMILIMVVILQLR 7.0 -38.1° 3.2 35.0 -3.1
Prolines* TKPWAVYAGLLGGVIMILIMVVILQLR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 243, GLY, HA2 A, 242, ALA, O 2.74Å
B, 246, GLY, HA1 A, 243, GLY, O 2.91Å
A, 243, GLY, HA2 B, 242, ALA, O 2.74Å
A, 246, GLY, HA1 B, 243, GLY, O 2.91Å