BMP and activin membrane-bound inhibitor homolog

UniProt data

UniProt name: BAMBI_HUMAN (Q13145)

Gene name: BAMBI; Synonyms=NMA

Organism: Homo sapiens (Human).

Function: Negatively regulates TGF-beta signaling.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 153-173, 21 AA, Helical. {ECO:0000255}.

Sequence: 260 AA

10 20 30 40 50 60 MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN 70 80 90 100 110 120 SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA 130 140 150 160 170 180 SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RAAVIAVPIA GGLILVLLIM LALRMLRSEN 190 200 210 220 230 240 KRLQDQRQQM LSRLHYSFHG HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSND 250 KILSLVHWGM YSGHGKLEFV

CATM prediction

The sequence of BAMBI_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  150       160       170    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 FRAAVIAVAIAGGLILVLLIMLALRML 7.4 -54.0° 3.6 49.1 -25.0
Prolines* FRAAVIAVPIAGGLILVLLIMLALRML          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 159, ILE, HA A, 158, ALA, O 3.35Å
B, 162, GLY, HA1 A, 159, ILE, O 3.40Å
A, 159, ILE, HA B, 158, ALA, O 3.35Å
A, 162, GLY, HA1 B, 159, ILE, O 3.40Å