Vesicular integral-membrane protein VIP36

UniProt data

UniProt name: LMAN2_HUMAN (Q12907)

Gene name: LMAN2; Synonyms=C5orf8

Organism: Homo sapiens (Human).

Function: Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity). {ECO:0000250}.

Subcellular location: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}. Golgi apparatus membrane {ECO:0000269|PubMed:10444376}; Single-pass membrane protein {ECO:0000269|PubMed:10444376}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10444376}; Single-pass type I membrane protein {ECO:0000269|PubMed:10444376}.

Transmembrane domains:

  1. 323-345, 23 AA, Helical. {ECO:0000255}.

Sequence: 356 AA

10 20 30 40 50 60 MAAEGWIWRW GWGRRCLGRP GLLGPGPGPT TPLFLLLLLG SVTADITDGN SEHLKREHSL 70 80 90 100 110 120 IKPYQGVGSS SMPLWDFQGS TMLTSQYVRL TPDERSKEGS IWNHQPCFLK DWEMHVHFKV 130 140 150 160 170 180 HGTGKKNLHG DGIALWYTRD RLVPGPVFGS KDNFHGLAIF LDTYPNDETT ERVFPYISVM 190 200 210 220 230 240 VNNGSLSYDH SKDGRWTELA GCTADFRNRD HDTFLAVRYS RGRLTVMTDL EDKNEWKNCI 250 260 270 280 290 300 DITGVRLPTG YYFGASAGTG DLSDNHDIIS MKLFQLMVEH TPDEESIDWT KIEPSVNFLK 310 320 330 340 350 SPKDNVDDPT GNFRSGPLTG WRVFLLLLCA LLGIVVCAVV GAVVFQKRQE RNKRFY

CATM prediction

The sequence of LMAN2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  320       330       340      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GWRVFLLLLCALLGIVVCAVVGAVVFQKR 7.2 -47.0° 2.3 44.9 -28.9
Model 2 GWRVFLLLLCALLGIVVCAVVGAVVFQKR 6.5 -53.3° 1.9 45.1 -16.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 330, ALA, HA A, 329, CYS, O 3.41Å
B, 333, GLY, HA1 A, 330, ALA, O 3.27Å
A, 330, ALA, HA B, 329, CYS, O 3.41Å
A, 333, GLY, HA1 B, 330, ALA, O 3.27Å