Cadherin-17

UniProt data

UniProt name: CAD17_HUMAN (Q12864)

Gene name: CDH17

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269|PubMed:8153632}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 788-808, 21 AA, Helical. {ECO:0000255}.

Sequence: 832 AA

10 20 30 40 50 60 MILQAHLHSL CLLMLYLATG YGQEGKFSGP LKPMTFSIYE GQEPSQIIFQ FKANPPAVTF 70 80 90 100 110 120 ELTGETDNIF VIEREGLLYY NRALDRETRS THNLQVAALD ANGIIVEGPV PITIKVKDIN 130 140 150 160 170 180 DNRPTFLQSK YEGSVRQNSR PGKPFLYVNA TDLDDPATPN GQLYYQIVIQ LPMINNVMYF 190 200 210 220 230 240 QINNKTGAIS LTREGSQELN PAKNPSYNLV ISVKDMGGQS ENSFSDTTSV DIIVTENIWK 250 260 270 280 290 300 APKPVEMVEN STDPHPIKIT QVRWNDPGAQ YSLVDKEKLP RFPFSIDQEG DIYVTQPLDR 310 320 330 340 350 360 EEKDAYVFYA VAKDEYGKPL SYPLEIHVKV KDINDNPPTC PSPVTVFEVQ ENERLGNSIG 370 380 390 400 410 420 TLTAHDRDEE NTANSFLNYR IVEQTPKLPM DGLFLIQTYA GMLQLAKQSL KKQDTPQYNL 430 440 450 460 470 480 TIEVSDKDFK TLCFVQINVI DINDQIPIFE KSDYGNLTLA EDTNIGSTIL TIQATDADEP 490 500 510 520 530 540 FTGSSKILYH IIKGDSEGRL GVDTDPHTNT GYVIIKKPLD FETAAVSNIV FKAENPEPLV 550 560 570 580 590 600 FGVKYNASSF AKFTLIVTDV NEAPQFSQHV FQAKVSEDVA IGTKVGNVTA KDPEGLDISY 610 620 630 640 650 660 SLRGDTRGWL KIDHVTGEIF SVAPLDREAG SPYRVQVVAT EVGGSSLSSV SEFHLILMDV 670 680 690 700 710 720 NDNPPRLAKD YTGLFFCHPL SAPGSLIFEA TDDDQHLFRG PHFTFSLGSG SLQNDWEVSK 730 740 750 760 770 780 INGTHARLST RHTEFEEREY VVLIRINDGG RPPLEGIVSL PVTFCSCVEG SCFRPAGHQT 790 800 810 820 830 GIPTVGMAVG ILLTTLLVIG IILAVVFIRI KKDKGKDNVE SAQASEVKPL RS

CATM prediction

The sequence of CAD17_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       790       800       81
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 VGMAVGILLTTLLVIGIILAVVFIRIK 7.1 -55.0° 0.9 50.1 -26.9
Model 2 VGMAVGILLTTLLVIGIILAVVFIRIK 7.4 -41.0° 3.5 38.0 -14.9
Model 3 VGMAVGILLTTLLVIGIILAVVFIRIK 6.8 -47.0° 6.0 45.0 -6.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 800, GLY, HA1 A, 797, LEU, O 3.23Å
B, 801, ILE, HA A, 800, GLY, O 3.31Å
A, 800, GLY, HA1 B, 797, LEU, O 3.23Å
A, 801, ILE, HA B, 800, GLY, O 3.31Å