Zona pellucida sperm-binding protein 4

UniProt data

UniProt name: ZP4_HUMAN (Q12836)

Gene name: ZP4; Synonyms=ZPB

Organism: Homo sapiens (Human).

Function: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q00193}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 506-526, 21 AA, Helical. {ECO:0000255}.

Sequence: 540 AA

10 20 30 40 50 60 MWLLRCVLLC VSLSLAVSGQ HKPEAPDYSS VLHCGPWSFQ FAVNLNQEAT SPPVLIAWDN 70 80 90 100 110 120 QGLLHELQND SDCGTWIRKG PGSSVVLEAT YSSCYVTEWD SHYIMPVGVE GAGAAEHKVV 130 140 150 160 170 180 TERKLLKCPM DLLARDAPDT DWCDSIPARD RLPCAPSPIS RGDCEGLGCC YSSEEVNSCY 190 200 210 220 230 240 YGNTVTLHCT REGHFSIAVS RNVTSPPLLL DSVRLALRND SACNPVMATQ AFVLFQFPFT 250 260 270 280 290 300 SCGTTRQITG DRAVYENELV ATRDVKNGSR GSVTRDSIFR LHVSCSYSVS SNSLPINVQV 310 320 330 340 350 360 FTLPPPFPET QPGPLTLELQ IAKDKNYGSY YGVGDYPVVK LLRDPIYVEV SILHRTDPYL 370 380 390 400 410 420 GLLLQQCWAT PSTDPLSQPQ WPILVKGCPY IGDNYQTQLI PVQKALDLPF PSHHQRFSIF 430 440 450 460 470 480 TFSFVNPTVE KQALRGPVHL HCSVSVCQPA ETPSCVVTCP DLSRRRNFDN SSQNTTASVS 490 500 510 520 530 SKGPMILLQA TKDPPEKLRV PVDSKVLWVA GLSGTLILGA LLVSYLAVKK QKSCPDQMCQ

CATM prediction

The sequence of ZP4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         510       520       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 DSKVLWVAGLSGTLILGALLVSYLAVK 6.8 -55.1° 4.2 38.0 -13.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 511, GLY, HA2 A, 510, ALA, O 2.80Å
B, 514, GLY, HA1 A, 511, GLY, O 3.04Å
A, 511, GLY, HA2 B, 510, ALA, O 2.80Å
A, 514, GLY, HA1 B, 511, GLY, O 3.04Å