Aspartyl/asparaginyl beta-hydroxylase

UniProt data

UniProt name: ASPH_HUMAN (Q12797)

Gene name: ASPH; Synonyms=BAH

Organism: Homo sapiens (Human).

Function: Isoform 8: membrane-bound Ca(2+)-sensing protein, which is a structural component of the ER-plasma membrane junctions. Isoform 8 regulates the activity of Ca(+2) released-activated Ca(+2) (CRAC) channels in T-cells. {ECO:0000269|PubMed:22586105}.

Subcellular location: Isoform 8: Endoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:22586105}.

Transmembrane domains:

  1. 54-74, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 758 AA

10 20 30 40 50 60 MAQRKNAKSS GNSSSSGSGS GSTSAGSSSP GARRETKHGG HKNGRKGGLS GTSFFTWFMV 70 80 90 100 110 120 IALLGVWTSV AVVWFDLVDY EEVLGKLGIY DADGDGDFDV DDAKVLLGLK ERSTSEPAVP 130 140 150 160 170 180 PEEAEPHTEP EEQVPVEAEP QNIEDEAKEQ IQSLLHEMVH AEHVEGEDLQ QEDGPTGEPQ 190 200 210 220 230 240 QEDDEFLMAT DVDDRFETLE PEVSHEETEH SYHVEETVSQ DCNQDMEEMM SEQENPDSSE 250 260 270 280 290 300 PVVEDERLHH DTDDVTYQVY EEQAVYEPLE NEGIEITEVT APPEDNPVED SQVIVEEVSI 310 320 330 340 350 360 FPVEEQQEVP PETNRKTDDP EQKAKVKKKK PKLLNKFDKT IKAELDAAEK LRKRGKIEEA 370 380 390 400 410 420 VNAFKELVRK YPQSPRARYG KAQCEDDLAE KRRSNEVLRG AIETYQEVAS LPDVPADLLK 430 440 450 460 470 480 LSLKRRSDRQ QFLGHMRGSL LTLQRLVQLF PNDTSLKNDL GVGYLLIGDN DNAKKVYEEV 490 500 510 520 530 540 LSVTPNDGFA KVHYGFILKA QNKIAESIPY LKEGIESGDP GTDDGRFYFH LGDAMQRVGN 550 560 570 580 590 600 KEAYKWYELG HKRGHFASVW QRSLYNVNGL KAQPWWTPKE TGYTELVKSL ERNWKLIRDE 610 620 630 640 650 660 GLAVMDKAKG LFLPEDENLR EKGDWSQFTL WQQGRRNENA CKGAPKTCTL LEKFPETTGC 670 680 690 700 710 720 RRGQIKYSIM HPGTHVWPHT GPTNCRLRMH LGLVIPKEGC KIRCANETKT WEEGKVLIFD 730 740 750 DSFEHEVWQD ASSFRLIFIV DVWHPELTPQ QRRSLPAI

CATM prediction

The sequence of ASPH_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           60        70      
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 GTSFFTWFMVIALLGVWTSVAVVWFDL 7.2 -44.2° 1.8 44.9 -21.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 62, ALA, HA A, 61, ILE, O 3.40Å
B, 65, GLY, HA1 A, 62, ALA, O 3.18Å
B, 66, VAL, HA A, 65, GLY, O 3.46Å
B, 69, SER, HG1 A, 66, VAL, O 2.53Å
A, 62, ALA, HA B, 61, ILE, O 3.40Å
A, 65, GLY, HA1 B, 62, ALA, O 3.18Å
A, 66, VAL, HA B, 65, GLY, O 3.46Å
A, 69, SER, HG1 B, 66, VAL, O 2.53Å