Alpha-(1,3)-fucosyltransferase 5

UniProt data

UniProt name: FUT5_HUMAN (Q11128)

Gene name: FUT5

Organism: Homo sapiens (Human).

Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Transmembrane domains:

  1. 16-34, 19 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 374 AA

10 20 30 40 50 60 MDPLGPAKPQ WLWRRCLAGL LFQLLVAVCF FSYLRVSRDD ATGSPRPGLM AVEPVTGAPN 70 80 90 100 110 120 GSRCQDSMAT PAHPTLLILL WTWPFNTPVA LPRCSEMVPG AADCNITADS SVYPQADAVI 130 140 150 160 170 180 VHHWDIMYNP SANLPPPTRP QGQRWIWFSM ESPSNCRHLE ALDGYFNLTM SYRSDSDIFT 190 200 210 220 230 240 PYGWLEPWSG QPAHPPLNLS AKTELVAWAV SNWKPDSARV RYYQSLQAHL KVDVYGRSHK 250 260 270 280 290 300 PLPKGTMMET LSRYKFYLAF ENSLHPDYIT EKLWRNALEA WAVPVVLGPS RSNYERFLPP 310 320 330 340 350 360 DAFIHVDDFQ SPKDLARYLQ ELDKDHARYL SYFRWRETLR PRSFSWALAF CKACWKLQQE 370 SRYQTVRSIA AWFT

CATM prediction

The sequence of FUT5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         20        30      
  +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 WRRCLAGLLFQLLVAVCFFSYLRVS 7.4 -50.0° 2.9 47.0 -15.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 19, GLY, HA1 A, 16, CYS, O 3.37Å
A, 19, GLY, HA1 B, 16, CYS, O 3.37Å