Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

UniProt data

UniProt name: MGT5A_HUMAN (Q09328)

Gene name: MGAT5; Synonyms=GGNT5

Organism: Homo sapiens (Human).

Function: Catalyzes the addition of N-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein.

Transmembrane domains:

  1. 14-30, 17 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 741 AA

10 20 30 40 50 60 MALFTPWKLS SQKLGFFLVT FGFIWGMMLL HFTIQQRTQP ESSSMLREQI LDLSKRYIKA 70 80 90 100 110 120 LAEENRNVVD GPYAGVMTAY DLKKTLAVLL DNILQRIGKL ESKVDNLVVN GTGTNSTNST 130 140 150 160 170 180 TAVPSLVALE KINVADIING AQEKCVLPPM DGYPHCEGKI KWMKDMWRSD PCYADYGVDG 190 200 210 220 230 240 STCSFFIYLS EVENWCPHLP WRAKNPYEEA DHNSLAEIRT DFNILYSMMK KHEEFRWMRL 250 260 270 280 290 300 RIRRMADAWI QAIKSLAEKQ NLEKRKRKKV LVHLGLLTKE SGFKIAETAF SGGPLGELVQ 310 320 330 340 350 360 WSDLITSLYL LGHDIRISAS LAELKEIMKK VVGNRSGCPT VGDRIVELIY IDIVGLAQFK 370 380 390 400 410 420 KTLGPSWVHY QCMLRVLDSF GTEPEFNHAN YAQSKGHKTP WGKWNLNPQQ FYTMFPHTPD 430 440 450 460 470 480 NSFLGFVVEQ HLNSSDIHHI NEIKRQNQSL VYGKVDSFWK NKKIYLDIIH TYMEVHATVY 490 500 510 520 530 540 GSSTKNIPSY VKNHGILSGR DLQFLLRETK LFVGLGFPYE GPAPLEAIAN GCAFLNPKFN 550 560 570 580 590 600 PPKSSKNTDF FIGKPTLREL TSQHPYAEVF IGRPHVWTVD LNNQEEVEDA VKAILNQKIE 610 620 630 640 650 660 PYMPYEFTCE GMLQRINAFI EKQDFCHGQV MWPPLSALQV KLAEPGQSCK QVCQESQLIC 670 680 690 700 710 720 EPSFFQHLNK DKDMLKYKVT CQSSELAKDI LVPSFDPKNK HCVFQGDLLL FSCAGAHPRH 730 740 QRVCPCRDFI KGQVALCKDC L

CATM prediction

The sequence of MGT5A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           20        30  
    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SQKLGFFLVTFGFIWGMMLLHFT 7.3 -51.0° 2.4 45.1 -13.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 19, VAL, HA A, 18, LEU, O 3.44Å
B, 22, GLY, HA1 A, 19, VAL, O 3.26Å
A, 19, VAL, HA B, 18, LEU, O 3.44Å
A, 22, GLY, HA1 B, 19, VAL, O 3.26Å