Myotonin-protein kinase

UniProt data

UniProt name: DMPK_HUMAN (Q09013)

Gene name: DMPK; Synonyms=DM1PK, MDPK

Organism: Homo sapiens (Human).

Function: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. {ECO:0000269|PubMed:10811636, ECO:0000269|PubMed:10913253, ECO:0000269|PubMed:11287000, ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949239}.

Subcellular location: Isoform 3: Mitochondrion membrane.

Transmembrane domains:

  1. 591-611, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 629 AA

10 20 30 40 50 60 MSAEVRLRRL QQLVLDPGFL GLEPLLDLLL GVHQELGASE LAQDKYVADF LQWAEPIVVR 70 80 90 100 110 120 LKEVRLQRDD FEILKVIGRG AFSEVAVVKM KQTGQVYAMK IMNKWDMLKR GEVSCFREER 130 140 150 160 170 180 DVLVNGDRRW ITQLHFAFQD ENYLYLVMEY YVGGDLLTLL SKFGERIPAE MARFYLAEIV 190 200 210 220 230 240 MAIDSVHRLG YVHRDIKPDN ILLDRCGHIR LADFGSCLKL RADGTVRSLV AVGTPDYLSP 250 260 270 280 290 300 EILQAVGGGP GTGSYGPECD WWALGVFAYE MFYGQTPFYA DSTAETYGKI VHYKEHLSLP 310 320 330 340 350 360 LVDEGVPEEA RDFIQRLLCP PETRLGRGGA GDFRTHPFFF GLDWDGLRDS VPPFTPDFEG 370 380 390 400 410 420 ATDTCNFDLV EDGLTAMVSG GGETLSDIRE GAPLGVHLPF VGYSYSCMAL RDSEVPGPTP 430 440 450 460 470 480 MELEAEQLLE PHVQAPSLEP SVSPQDETAE VAVPAAVPAA EAEAEVTLRE LQEALEEEVL 490 500 510 520 530 540 TRQSLSREME AIRTDNQNFA SQLREAEARN RDLEAHVRQL QERMELLQAE GATAVTGVPS 550 560 570 580 590 600 PRATDPPSHL DGPPAVAVGQ CPLVGPGPMH RRHLLLPARV PRPGLSEALS LLLFAVVLSR 610 620 AAALGCIGLV AHAGQLTAVW RRPGAARAP

CATM prediction

The sequence of DMPK_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    590       600       610  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ALSLLLFAVVLSRAAALGCIGLVAHAG 7.0 -54.9° 4.2 37.8 -14.3
Model 2 ALSLLLFAVVLSRAAALGCIGLVAHAG 7.0 +53.2° 2.1 96.3 -0.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 602, ALA, HA A, 601, ALA, O 3.01Å
B, 605, GLY, HA1 A, 602, ALA, O 3.20Å
A, 602, ALA, HA B, 601, ALA, O 3.01Å
A, 605, GLY, HA1 B, 602, ALA, O 3.20Å