Sialic acid-binding Ig-like lectin 14

UniProt data

UniProt name: SIG14_HUMAN (Q08ET2)

Gene name: SIGLEC14; ORFNames=UNQ294/PRO333

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. {ECO:0000269|PubMed:17012248}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:17012248}; Single-pass type I membrane protein {ECO:0000269|PubMed:17012248}.

Transmembrane domains:

  1. 359-381, 23 AA, Helical. {ECO:0000255}.

Sequence: 396 AA

10 20 30 40 50 60 MLPLLLLPLL WGGSLQEKPV YELQVQKSVT VQEGLCVLVP CSFSYPWRSW YSSPPLYVYW 70 80 90 100 110 120 FRDGEIPYYA EVVATNNPDR RVKPETQGRF RLLGDVQKKN CSLSIGDARM EDTGSYFFRV 130 140 150 160 170 180 ERGRDVKYSY QQNKLNLEVT ALIEKPDIHF LEPLESGRPT RLSCSLPGSC EAGPPLTFSW 190 200 210 220 230 240 TGNALSPLDP ETTRSSELTL TPRPEDHGTN LTCQVKRQGA QVTTERTVQL NVSYAPQNLA 250 260 270 280 290 300 ISIFFRNGTG TALRILSNGM SVPIQEGQSL FLACTVDSNP PASLSWFREG KALNPSQTSM 310 320 330 340 350 360 SGTLELPNIG AREGGEFTCR VQHPLGSQHL SFILSVQRSS SSCICVTEKQ QGSWPLVLTL 370 380 390 IRGALMGAGF LLTYGLTWIY YTRCGGPQQS RAERPG

CATM prediction

The sequence of SIG14_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      360       370       380  
    |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LVLTLIRGALMGAGFLLTYGLTWIYYTRC 6.3 -53.9° 4.8 40.9 -42.8
Model 2 LVLTLIRGALMGAGFLLTYGLTWIYYTRC 7.2 -54.9° 2.4 47.9 -26.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 363, GLY, HA1 A, 360, LEU, O 3.08Å
B, 364, ALA, HA A, 363, GLY, O 2.29Å
B, 364, ALA, HA A, 364, ALA, O 3.41Å
B, 367, GLY, HA1 A, 364, ALA, O 2.72Å
A, 363, GLY, HA1 B, 360, LEU, O 3.08Å
A, 364, ALA, HA B, 363, GLY, O 2.29Å
A, 364, ALA, HA B, 364, ALA, O 3.41Å
A, 367, GLY, HA1 B, 364, ALA, O 2.72Å