Desmocollin-1

UniProt data

UniProt name: DSC1_HUMAN (Q08554)

Gene name: DSC1; Synonyms=CDHF1

Organism: Homo sapiens (Human).

Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.

Transmembrane domains:

  1. 692-714, 23 AA, Helical. {ECO:0000255}.

Sequence: 894 AA

10 20 30 40 50 60 MALASAAPGS IFCKQLLFSL LVLTLLCDAC QKVYLRVPSH LQAETLVGKV NLEECLKSAS 70 80 90 100 110 120 LIRSSDPAFR ILEDGSIYTT HDLILSSERK SFSIFLSDGQ RREQQEIKVV LSARENKSPK 130 140 150 160 170 180 KRHTKDTALK RSKRRWAPIP ASLMENSLGP FPQHVQQIQS DAAQNYTIFY SISGPGVDKE 190 200 210 220 230 240 PFNLFYIEKD TGDIFCTRSI DREKYEQFAL YGYATTADGY APEYPLPLII KIEDDNDNAP 250 260 270 280 290 300 YFEHRVTIFT VPENCRSGTS VGKVTATDLD EPDTLHTRLK YKILQQIPDH PKHFSIHPDT 310 320 330 340 350 360 GVITTTTPFL DREKCDTYQL IMEVRDMGGQ PFGLFNTGTI TISLEDENDN PPSFTETSYV 370 380 390 400 410 420 TEVEENRIDV EILRMKVQDQ DLPNTPHSKA VYKILQGNEN GNFIISTDPN TNEGVLCVVK 430 440 450 460 470 480 PLNYEVNRQV ILQVGVINEA QFSKAASSQT PTMCTTTVTV KIIDSDEGPE CHPPVKVIQS 490 500 510 520 530 540 QDGFPAGQEL LGYKALDPEI SSGEGLRYQK LGDEDNWFEI NQHTGDLRTL KVLDRESKFV 550 560 570 580 590 600 KNNQYNISVV AVDAVGRSCT GTLVVHLDDY NDHAPQIDKE VTICQNNEDF AVLKPVDPDG 610 620 630 640 650 660 PENGPPFQFF LDNSASKNWN IEEKDGKTAI LRQRQNLDYN YYSVPIQIKD RHGLVATHML 670 680 690 700 710 720 TVRVCDCSTP SECRMKDKST RDVRPNVILG RWAILAMVLG SVLLLCILFT CFCVTAKRTV 730 740 750 760 770 780 KKCFPEDIAQ QNLIVSNTEG PGEEVTEANI RLPMQTSNIC DTSMSVGTVG GQGIKTQQSF 790 800 810 820 830 840 EMVKGGYTLD SNKGGGHQTL ESVKGVGQGD TGRYAYTDWQ SFTQPRLGEK VYLCGQDEEH 850 860 870 880 890 KHCEDYVCSY NYEGKGSLAG SVGCCSDRQE EEGLEFLDHL EPKFRTLAKT CIKK

CATM prediction

The sequence of DSC1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   690       700       710     
 |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 LGRWAILAMVLGSVLLLCILFTCFCVTAK 7.1 -55.0° 4.2 37.5 -19.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 697, MET, HA A, 696, ALA, O 2.60Å
B, 700, GLY, HA1 A, 697, MET, O 2.72Å
A, 697, MET, HA B, 696, ALA, O 2.60Å
A, 700, GLY, HA1 B, 697, MET, O 2.72Å