Protocadherin-1

UniProt data

UniProt name: PCDH1_HUMAN (Q08174)

Gene name: PCDH1

Organism: Homo sapiens (Human).

Function: May be involved in cell-cell interaction processes and in cell adhesion.

Subcellular location: Cell junction. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.

Transmembrane domains:

  1. 853-873, 21 AA, Helical. {ECO:0000255}.

Sequence: 1060 AA

10 20 30 40 50 60 MDSGAGGRRC PEAALLILGP PRMEHLRHSP GPGGQRLLLP SMLLALLLLL APSPGHATRV 70 80 90 100 110 120 VYKVPEEQPP NTLIGSLAAD YGFPDVGHLY KLEVGAPYLR VDGKTGDIFT TETSIDREGL 130 140 150 160 170 180 RECQNQLPGD PCILEFEVSI TDLVQNGSPR LLEGQIEVQD INDNTPNFAS PVITLAIPEN 190 200 210 220 230 240 TNIGSLFPIP LASDRDAGPN GVASYELQAG PEAQELFGLQ VAEDQEEKQP QLIVMGNLDR 250 260 270 280 290 300 ERWDSYDLTI KVQDGGSPPR ASSALLRVTV LDTNDNAPKF ERPSYEAELS ENSPIGHSVI 310 320 330 340 350 360 QVKANDSDQG ANAEIEYTFH QAPEVVRRLL RLDRNTGLIT VQGPVDREDL STLRFSVLAK 370 380 390 400 410 420 DRGTNPKSAR AQVVVTVKDM NDNAPTIEIR GIGLVTHQDG MANISEDVAE ETAVALVQVS 430 440 450 460 470 480 DRDEGENAAV TCVVAGDVPF QLRQASETGS DSKKKYFLQT TTPLDYEKVK DYTIEIVAVD 490 500 510 520 530 540 SGNPPLSSTN SLKVQVVDVN DNAPVFTQSV TEVAFPENNK PGEVIAEITA SDADSGSNAE 550 560 570 580 590 600 LVYSLEPEPA AKGLFTISPE TGEIQVKTSL DREQRESYEL KVVAADRGSP SLQGTATVLV 610 620 630 640 650 660 NVLDCNDNDP KFMLSGYNFS VMENMPALSP VGMVTVIDGD KGENAQVQLS VEQDNGDFVI 670 680 690 700 710 720 QNGTGTILSS LSFDREQQST YTFQLKAVDG GVPPRSAYVG VTINVLDEND NAPYITAPSN 730 740 750 760 770 780 TSHKLLTPQT RLGETVSQVA AEDFDSGVNA ELIYSIAGGN PYGLFQIGSH SGAITLEKEI 790 800 810 820 830 840 ERRHHGLHRL VVKVSDRGKP PRYGTALVHL YVNETLANRT LLETLLGHSL DTPLDIDIAG 850 860 870 880 890 900 DPEYERSKQR GNILFGVVAG VVAVALLIAL AVLVRYCRQR EAKSGYQAGK KETKDLYAPK 910 920 930 940 950 960 PSGKASKGNK SKGKKSKSPK PVKPVEDEDE AGLQKSLKFN LMSDAPGDSP RIHLPLNYPP 970 980 990 1000 1010 1020 GSPDLGRHYR SNSPLPSIQL QPQSPSASKK HQVVQDLPPA NTFVGTGDTT STGSEQYSDY 1030 1040 1050 SYRTNPPKYP SKQVGQPFQL STPQPLPHPY HGAIWTEVWE

CATM prediction

The sequence of PCDH1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  850       860       870    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 RGNILFGVVAGVVAVALLIALAVLVRY 6.6 -47.7° 0.7 54.0 -34.0
Model 2 RGNILFGVVAGVVAVALLIALAVLVRY 7.3 -54.0° 3.6 49.0 -11.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 856, GLY, HA1 A, 853, ILE, O 2.81Å
B, 857, VAL, HA A, 856, GLY, O 2.85Å
A, 856, GLY, HA1 B, 853, ILE, O 2.81Å
A, 857, VAL, HA B, 856, GLY, O 2.85Å