Induced myeloid leukemia cell differentiation protein Mcl-1

UniProt data

UniProt name: MCL1_HUMAN (Q07820)

Gene name: MCL1; Synonyms=BCL2L3

Organism: Homo sapiens (Human).

Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

Transmembrane domains:

  1. 328-348, 21 AA, Helical. {ECO:0000255}.

Sequence: 350 AA

10 20 30 40 50 60 MFGLKRNAVI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS 70 80 90 100 110 120 AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM 130 140 150 160 170 180 SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE 190 200 210 220 230 240 IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE 250 260 270 280 290 300 DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR 310 320 330 340 TKRDWLVKQR GWDGFVEFFH VEDLEGGIRN VLLAFAGVAG VGAGLAYLIR

CATM prediction

The sequence of MCL1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       330       340       3
+    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 EGGIRNVLLAFAGVAGVGAGLAYLIR 6.8 -47.0° 1.3 44.9 -18.2
Model 2 EGGIRNVLLAFAGVAGVGAGLAYLIR 7.2 -35.9° 2.4 59.1 -6.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 339, ALA, HA A, 338, VAL, O 3.15Å
B, 342, GLY, HA1 A, 339, ALA, O 2.80Å
B, 343, ALA, HA A, 342, GLY, O 3.16Å
B, 346, ALA, HA A, 347, TYR, OH 2.96Å
A, 339, ALA, HA B, 338, VAL, O 3.15Å
A, 342, GLY, HA1 B, 339, ALA, O 2.80Å
A, 343, ALA, HA B, 342, GLY, O 3.16Å
A, 346, ALA, HA B, 347, TYR, OH 2.96Å