Glutamyl aminopeptidase

UniProt data

UniProt name: AMPE_HUMAN (Q07075)

Gene name: ENPEP

Organism: Homo sapiens (Human).

Function: Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells.

Subcellular location: Membrane; Single-pass type II membrane protein.

Transmembrane domains:

  1. 19-39, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 957 AA

10 20 30 40 50 60 MNFAEREGSK RYCIQTKHVA ILCAVVVGVG LIVGLAVGLT RSCDSSGDGG PGTAPAPSHL 70 80 90 100 110 120 PSSTASPSGP PAQDQDICPA SEDESGQWKN FRLPDFVNPV HYDLHVKPLL EEDTYTGTVS 130 140 150 160 170 180 ISINLSAPTR YLWLHLRETR ITRLPELKRP SGDQVQVRRC FEYKKQEYVV VEAEEELTPS 190 200 210 220 230 240 SGDGLYLLTM EFAGWLNGSL VGFYRTTYTE NGQVKSIVAT DHEPTDARKS FPCFDEPNKK 250 260 270 280 290 300 ATYTISITHP KEYGALSNMP VAKEESVDDK WTRTTFEKSV PMSTYLVCFA VHQFDSVKRI 310 320 330 340 350 360 SNSGKPLTIY VQPEQKHTAE YAANITKSVF DYFEEYFAMN YSLPKLDKIA IPDFGTGAME 370 380 390 400 410 420 NWGLITYRET NLLYDPKESA SSNQQRVATV VAHELVHQWF GNIVTMDWWE DLWLNEGFAS 430 440 450 460 470 480 FFEFLGVNHA ETDWQMRDQM LLEDVLPVQE DDSLMSSHPI IVTVTTPDEI TSVFDGISYS 490 500 510 520 530 540 KGSSILRMLE DWIKPENFQK GCQMYLEKYQ FKNAKTSDFW AALEEASRLP VKEVMDTWTR 550 560 570 580 590 600 QMGYPVLNVN GVKNITQKRF LLDPRANPSQ PPSDLGYTWN IPVKWTEDNI TSSVLFNRSE 610 620 630 640 650 660 KEGITLNSSN PSGNAFLKIN PDHIGFYRVN YEVATWDSIA TALSLNHKTF SSADRASLID 670 680 690 700 710 720 DAFALARAQL LDYKVALNLT KYLKREENFL PWQRVISAVT YIISMFEDDK ELYPMIEEYF 730 740 750 760 770 780 QGQVKPIADS LGWNDAGDHV TKLLRSSVLG FACKMGDREA LNNASSLFEQ WLNGTVSLPV 790 800 810 820 830 840 NLRLLVYRYG MQNSGNEISW NYTLEQYQKT SLAQEKEKLL YGLASVKNVT LLSRYLDLLK 850 860 870 880 890 900 DTNLIKTQDV FTVIRYISYN SYGKNMAWNW IQLNWDYLVN RYTLNNRNLG RIVTIAEPFN 910 920 930 940 950 TELQLWQMES FFAKYPQAGA GEKPREQVLE TVKNNIEWLK QHRNTIREWF FNLLESG

CATM prediction

The sequence of AMPE_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      20        30        40 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 TKHVAILCAVVVGVGLIVGLAVGLTRS 6.4 -37.9° 1.5 45.3 -30.6
Model 2 TKHVAILCAVVVGVGLIVGLAVGLTRS 6.5 -51.0° 4.8 57.0 -13.3
Model 3 TKHVAILCAVVVGVGLIVGLAVGLTRS 7.2 -48.2° 0.0 38.1 -4.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 31, LEU, HA A, 30, GLY, O 2.55Å
B, 34, GLY, HA1 A, 31, LEU, O 2.41Å
B, 35, LEU, HA A, 34, GLY, O 2.47Å
B, 38, GLY, HA1 A, 35, LEU, O 3.44Å
A, 31, LEU, HA B, 30, GLY, O 2.55Å
A, 34, GLY, HA1 B, 31, LEU, O 2.41Å
A, 35, LEU, HA B, 34, GLY, O 2.47Å
A, 38, GLY, HA1 B, 35, LEU, O 3.44Å