Cytoskeleton-associated protein 4

UniProt data

UniProt name: CKAP4_HUMAN (Q07065)

Gene name: CKAP4

Organism: Homo sapiens (Human).

Function: Mediates the anchoring of the endoplasmic reticulum to microtubules.

Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Translocates to the perinuclear region upon APF- stimulation.

Transmembrane domains:

  1. 107-127, 21 AA, Helical. {ECO:0000255}.

Sequence: 602 AA

10 20 30 40 50 60 MPSAKQRGSK GGHGAASPSE KGAHPSGGAD DVAKKPPPAP QQPPPPPAPH PQQHPQQHPQ 70 80 90 100 110 120 NQAHGKGGHR GGGGGGGKSS SSSSASAAAA AAAASSSASC SRRLGRALNF LFYLALVAAA 130 140 150 160 170 180 AFSGWCVHHV LEEVQQVRRS HQDFSRQREE LGQGLQGVEQ KVQSLQATFG TFESILRSSQ 190 200 210 220 230 240 HKQDLTEKAV KQGESEVSRI SEVLQKLQNE ILKDLSDGIH VVKDARERDF TSLENTVEER 250 260 270 280 290 300 LTELTKSIND NIAIFTEVQK RSQKEINDMK AKVASLEESE GNKQDLKALK EAVKEIQTSA 310 320 330 340 350 360 KSREWDMEAL RSTLQTMESD IYTEVRELVS LKQEQQAFKE AADTERLALQ ALTEKLLRSE 370 380 390 400 410 420 ESVSRLPEEI RRLEEELRQL KSDSHGPKED GGFRHSEAFE ALQQKSQGLD SRLQHVEDGV 430 440 450 460 470 480 LSMQVASARQ TESLESLLSK SQEHEQRLAA LQGRLEGLGS SEADQDGLAS TVRSLGETQL 490 500 510 520 530 540 VLYGDVEELK RSVGELPSTV ESLQKVQEQV HTLLSQDQAQ AARLPPQDFL DRLSSLDNLK 550 560 570 580 590 600 ASVSQVEADL KMLRTAVDSL VAYSVKIETN ENNLESAKGL LDDLRNDLDR LFVKVEKIHE KV

CATM prediction

The sequence of CKAP4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        110       120       1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 LGRALNFLFYLALVAAAAFSGWCVHHV 7.4 -51.0° 3.3 48.1 -31.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 121, ALA, HA A, 120, ALA, O 3.35Å
B, 124, GLY, HA1 A, 121, ALA, O 3.41Å
A, 121, ALA, HA B, 120, ALA, O 3.35Å
A, 124, GLY, HA1 B, 121, ALA, O 3.41Å