Tyrosine-protein kinase receptor TYRO3

UniProt data

UniProt name: TYRO3_HUMAN (Q06418)

Gene name: TYRO3; Synonyms=BYK, DTK, RSE, SKY, TIF

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:25277499, PubMed:22156524, PubMed:22673088). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope (PubMed:17005688). {ECO:0000269|PubMed:17005688, ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 430-450, 21 AA, Helical. {ECO:0000255}.

Sequence: 890 AA

10 20 30 40 50 60 MALRRSMGRP GLPPLPLPPP PRLGLLLAAL ASLLLPESAA AGLKLMGAPV KLTVSQGQPV 70 80 90 100 110 120 KLNCSVEGME EPDIQWVKDG AVVQNLDQLY IPVSEQHWIG FLSLKSVERS DAGRYWCQVE 130 140 150 160 170 180 DGGETEISQP VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IVWWRGTTKI 190 200 210 220 230 240 GGPAPSPSVL NVTGVTQSTM FSCEAHNLKG LASSRTATVH LQALPAAPFN ITVTKLSSSN 250 260 270 280 290 300 ASVAWMPGAD GRALLQSCTV QVTQAPGGWE VLAVVVPVPP FTCLLRDLVP ATNYSLRVRC 310 320 330 340 350 360 ANALGPSPYA DWVPFQTKGL APASAPQNLH AIRTDSGLIL EWEEVIPEAP LEGPLGPYKL 370 380 390 400 410 420 SWVQDNGTQD ELTVEGTRAN LTGWDPQKDL IVRVCVSNAV GCGPWSQPLV VSSHDRAGQQ 430 440 450 460 470 480 GPPHSRTSWV PVVLGVLTAL VTAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA 490 500 510 520 530 540 RSFNRERPER IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE 550 560 570 580 590 600 DGSFVKVAVK MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM 610 620 630 640 650 660 VILPFMKHGD LHAFLLASRI GENPFNLPLQ TLIRFMVDIA CGMEYLSSRN FIHRDLAARN 670 680 690 700 710 720 CMLAEDMTVC VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VQSDVWAFGV 730 740 750 760 770 780 TMWEIMTRGQ TPYAGIENAE IYNYLIGGNR LKQPPECMED VYDLMYQCWS ADPKQRPSFT 790 800 810 820 830 840 CLRMELENIL GQLSVLSASQ DPLYINIERA EEPTAGGSLE LPGRDQPYSG AGDGSGMGAV 850 860 870 880 GGTPSDCRYI LTPGGLAEQP GQAEHQPESP LNETQRLLLL QQGLLPHSSC

CATM prediction

The sequence of TYRO3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     430       440       450 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 TSWVAVVLGVLTALVTAAALALILLRK 6.9 -46.0° 2.7 47.0 -19.5
Prolines* TSWVPVVLGVLTALVTAAALALILLRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 432, VAL, HA A, 431, ALA, O 2.90Å
B, 435, GLY, HA1 A, 432, VAL, O 2.86Å
B, 436, VAL, HA A, 435, GLY, O 3.46Å
A, 432, VAL, HA B, 431, ALA, O 2.90Å
A, 435, GLY, HA1 B, 432, VAL, O 2.86Å
A, 436, VAL, HA B, 435, GLY, O 3.46Å