Zona pellucida sperm-binding protein 2

UniProt data

UniProt name: ZP2_HUMAN (Q05996)

Gene name: ZP2; Synonyms=ZPA

Organism: Homo sapiens (Human).

Function: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. {ECO:0000250|UniProtKB:P20239}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:P20239}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20239}.

Transmembrane domains:

  1. 717-736, 20 AA, Helical. {ECO:0000255}.

Sequence: 745 AA

10 20 30 40 50 60 MACRQRGGSW SPSGWFNAGW STYRSISLFF ALVTSGNSID VSQLVNPAFP GTVTCDEREI 70 80 90 100 110 120 TVEFPSSPGT KKWHASVVDP LGLDMPNCTY ILDPEKLTLR ATYDNCTRRV HGGHQMTIRV 130 140 150 160 170 180 MNNSAALRHG AVMYQFFCPA MQVEETQGLS ASTICQKDFM SFSLPRVFSG LADDSKGTKV 190 200 210 220 230 240 QMGWSIEVGD GARAKTLTLP EAMKEGFSLL IDNHRMTFHV PFNATGVTHY VQGNSHLYMV 250 260 270 280 290 300 SLKLTFISPG QKVIFSSQAI CAPDPVTCNA THMTLTIPEF PGKLKSVSFE NQNIDVSQLH 310 320 330 340 350 360 DNGIDLEATN GMKLHFSKTL LKTKLSEKCL LHQFYLASLK LTFLLRPETV SMVIYPECLC 370 380 390 400 410 420 ESPVSIVTGE LCTQDGFMDV EVYSYQTQPA LDLGTLRVGN SSCQPVFEAQ SQGLVRFHIP 430 440 450 460 470 480 LNGCGTRYKF EDDKVVYENE IHALWTDFPP SKISRDSEFR MTVKCSYSRN DMLLNINVES 490 500 510 520 530 540 LTPPVASVKL GPFTLILQSY PDNSYQQPYG ENEYPLVRFL RQPIYMEVRV LNRDDPNIKL 550 560 570 580 590 600 VLDDCWATST MDPDSFPQWN VVVDGCAYDL DNYQTTFHPV GSSVTHPDHY QRFDMKAFAF 610 620 630 640 650 660 VSEAHVLSSL VYFHCSALIC NRLSPDSPLC SVTCPVSSRH RRATGATEAE KMTVSLPGPI 670 680 690 700 710 720 LLLSDDSSFR GVGSSDLKAS GSSGEKSRSE TGEEVGSRGA MDTKGHKTAG DVGSKAVAAV 730 740 AAFAGVVATL GFIYYLYEKR TVSNH

CATM prediction

The sequence of ZP2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        720       730       
 +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SKAVAAVAAFAGVVATLGFIYYLYEK 7.2 -40.0° 4.1 38.0 -12.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 722, ALA, HA A, 721, ALA, O 3.13Å
B, 725, GLY, HA1 A, 722, ALA, O 3.29Å
B, 726, VAL, HA A, 729, THR, OG1 2.63Å
A, 722, ALA, HA B, 721, ALA, O 3.13Å
A, 725, GLY, HA1 B, 722, ALA, O 3.29Å
A, 726, VAL, HA B, 729, THR, OG1 2.74Å