Sialomucin core protein 24

UniProt data

UniProt name: MUC24_HUMAN (Q04900)

Gene name: CD164

Organism: Homo sapiens (Human).

Function: Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity). {ECO:0000250, ECO:0000269|PubMed:16859559, ECO:0000269|PubMed:17077324, ECO:0000269|PubMed:9763543}.

Subcellular location: Isoform 2: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 163-183, 21 AA, Helical. {ECO:0000255}.

Sequence: 197 AA

10 20 30 40 50 60 MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL PLVTTPAPET 70 80 90 100 110 120 CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC QVGNTTDFCS VSTATPVPTA 130 140 150 160 170 180 NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT PTSQPVRKST FDAASFIGGI VLVLGVQAVI 190 FFLYKFCKSK ERNYHTL

CATM prediction

The sequence of MUC24_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  160       170       180    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 TFDAASFIGGIVLVLGVQAVIFFLYKF 7.4 -54.2° 2.8 51.0 -1.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 166, PHE, HA A, 165, SER, O 3.49Å
B, 169, GLY, HA1 A, 166, PHE, O 3.42Å
A, 166, PHE, HA B, 165, SER, O 3.49Å
A, 169, GLY, HA1 B, 166, PHE, O 3.42Å