Activin receptor type-1

UniProt data

UniProt name: ACVR1_HUMAN (Q04771)

Gene name: ACVR1; Synonyms=ACVRLK2

Organism: Homo sapiens (Human).

Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 124-146, 23 AA, Helical. {ECO:0000255}.

Sequence: 509 AA

10 20 30 40 50 60 MVDGVMILPV LIMIALPSPS MEDEKPKVNP KLYMCVCEGL SCGNEDHCEG QQCFSSLSIN 70 80 90 100 110 120 DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 130 140 150 160 170 180 HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 190 200 210 220 230 240 ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 250 260 270 280 290 300 DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 310 320 330 340 350 360 DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 370 380 390 400 410 420 HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 430 440 450 460 470 480 NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 490 500 NPSARLTALR IKKTLTKIDN SLDKLKTDC

CATM prediction

The sequence of ACVR1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           130       140       
    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 HLEVGLIILSVVFAVCLLACLLGVALRKF 6.9 -50.1° 2.8 46.9 -34.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 140, CYS, HA A, 139, ALA, O 3.00Å
B, 143, GLY, HA1 A, 140, CYS, O 2.97Å
A, 140, CYS, HA B, 139, ALA, O 3.00Å
A, 143, GLY, HA1 B, 140, CYS, O 2.97Å