Glutamate carboxypeptidase 2

UniProt data

UniProt name: FOLH1_HUMAN (Q04609)

Gene name: FOLH1; Synonyms=FOLH, NAALAD1, PSM, PSMA; ORFNames=GIG27

Organism: Homo sapiens (Human).

Function: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Subcellular location: Isoform PSMA': Cytoplasm {ECO:0000269|PubMed:9809977}.

Transmembrane domains:

  1. 20-43, 24 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000305}.

Sequence: 750 AA

10 20 30 40 50 60 MWNLLHETDS AVATARRPRW LCAGALVLAG GFFLLGFLFG WFIKSSNEAT NITPKHNMKA 70 80 90 100 110 120 FLDELKAENI KKFLYNFTQI PHLAGTEQNF QLAKQIQSQW KEFGLDSVEL AHYDVLLSYP 130 140 150 160 170 180 NKTHPNYISI INEDGNEIFN TSLFEPPPPG YENVSDIVPP FSAFSPQGMP EGDLVYVNYA 190 200 210 220 230 240 RTEDFFKLER DMKINCSGKI VIARYGKVFR GNKVKNAQLA GAKGVILYSD PADYFAPGVK 250 260 270 280 290 300 SYPDGWNLPG GGVQRGNILN LNGAGDPLTP GYPANEYAYR RGIAEAVGLP SIPVHPIGYY 310 320 330 340 350 360 DAQKLLEKMG GSAPPDSSWR GSLKVPYNVG PGFTGNFSTQ KVKMHIHSTN EVTRIYNVIG 370 380 390 400 410 420 TLRGAVEPDR YVILGGHRDS WVFGGIDPQS GAAVVHEIVR SFGTLKKEGW RPRRTILFAS 430 440 450 460 470 480 WDAEEFGLLG STEWAEENSR LLQERGVAYI NADSSIEGNY TLRVDCTPLM YSLVHNLTKE 490 500 510 520 530 540 LKSPDEGFEG KSLYESWTKK SPSPEFSGMP RISKLGSGND FEVFFQRLGI ASGRARYTKN 550 560 570 580 590 600 WETNKFSGYP LYHSVYETYE LVEKFYDPMF KYHLTVAQVR GGMVFELANS IVLPFDCRDY 610 620 630 640 650 660 AVVLRKYADK IYSISMKHPQ EMKTYSVSFD SLFSAVKNFT EIASKFSERL QDFDKSNPIV 670 680 690 700 710 720 LRMMNDQLMF LERAFIDPLG LPDRPFYRHV IYAPSSHNKY AGESFPGIYD ALFDIESKVD 730 740 PSKAWGEVKR QIYVAAFTVQ AAAETLSEVA

CATM prediction

The sequence of FOLH1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     20        30        40     
   |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 RARWLCAGALVLAGGFFLLGFLFGWFIKSS 7.0 -28.0° 3.1 47.9 -40.4
Model 2 RARWLCAGALVLAGGFFLLGFLFGWFIKSS 7.0 -47.1° 2.2 45.1 -24.9
Model 3 RARWLCAGALVLAGGFFLLGFLFGWFIKSS 6.8 -55.1° 3.6 62.8 -22.5
Model 4 RARWLCAGALVLAGGFFLLGFLFGWFIKSS 7.4 -52.0° 0.6 48.0 -1.7
Prolines* RPRWLCAGALVLAGGFFLLGFLFGWFIKSS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 33, PHE, HA A, 32, PHE, O 2.87Å
B, 36, GLY, HA1 A, 33, PHE, O 3.21Å
B, 37, PHE, HA A, 36, GLY, O 3.41Å
A, 33, PHE, HA B, 32, PHE, O 2.87Å
A, 36, GLY, HA1 B, 33, PHE, O 3.21Å
A, 37, PHE, HA B, 36, GLY, O 3.41Å