Transforming growth factor beta receptor type 3

UniProt data

UniProt name: TGBR3_HUMAN (Q03167)

Gene name: TGFBR3

Organism: Homo sapiens (Human).

Function: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

Subcellular location: Secreted. Secreted, extracellular space. Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Transmembrane domains:

  1. 788-809, 22 AA, Helical. {ECO:0000255}.

Sequence: 851 AA

10 20 30 40 50 60 MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL 70 80 90 100 110 120 PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA 130 140 150 160 170 180 TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA 190 200 210 220 230 240 RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP 250 260 270 280 290 300 NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI 310 320 330 340 350 360 GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNAE 370 380 390 400 410 420 EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG LPFPFPDISR RVWNEEGEDG 430 440 450 460 470 480 LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI ALSVKCDNEK MIVAVEKDSF QASGYSGMDV 490 500 510 520 530 540 TLLDPTCKAK MNGTHFVLES PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY 550 560 570 580 590 600 EDLESGDNGF PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT 610 620 630 640 650 660 DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM SHYTIIENIC 670 680 690 700 710 720 PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL LFLQCELTLC TKMEKHPQKL 730 740 750 760 770 780 PKCVPPDEAC TSLDASIIWA MMQNKKTFTK PLAVIHHEAE SKEKGPSMKE PNPISPPIFH 790 800 810 820 830 840 GLDTLTVMGI AFAAFVIGAL LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST 850 QSTPCSSSST A

CATM prediction

The sequence of TGBR3_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       790       800       810
+    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LTVMGIAFAAFVIGALLTGALWYIYSHT 7.2 -54.2° 2.8 51.1 -20.9
Model 2 LTVMGIAFAAFVIGALLTGALWYIYSHT 7.3 -47.0° 1.4 45.0 -8.3
Model 3 LTVMGIAFAAFVIGALLTGALWYIYSHT 7.4 -54.2° 2.8 51.4 -8.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 795, PHE, HA A, 794, ALA, O 3.32Å
B, 798, GLY, HA1 A, 795, PHE, O 3.20Å
B, 799, ALA, HA A, 802, THR, OG1 2.71Å
A, 795, PHE, HA B, 794, ALA, O 3.32Å
A, 798, GLY, HA1 B, 795, PHE, O 3.20Å
A, 799, ALA, HA B, 802, THR, OG1 2.71Å