Retinal guanylyl cyclase 1

UniProt data

UniProt name: GUC2D_HUMAN (Q02846)

Gene name: GUCY2D; Synonyms=CORD6, GUC1A4, GUC2D, RETGC, RETGC1

Organism: Homo sapiens (Human).

Function: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 463-487, 25 AA, Helical. {ECO:0000255}.

Sequence: 1103 AA

10 20 30 40 50 60 MTACARRAGG LPDPGLCGPA WWAPSLPRLP RALPRLPLLL LLLLLQPPAL SAVFTVGVLG 70 80 90 100 110 120 PWACDPIFSR ARPDLAARLA AARLNRDPGL AGGPRFEVAL LPEPCRTPGS LGAVSSALAR 130 140 150 160 170 180 VSGLVGPVNP AACRPAELLA EEAGIALVPW GCPWTQAEGT TAPAVTPAAD ALYALLRAFG 190 200 210 220 230 240 WARVALVTAP QDLWVEAGRS LSTALRARGL PVASVTSMEP LDLSGAREAL RKVRDGPRVT 250 260 270 280 290 300 AVIMVMHSVL LGGEEQRYLL EAAEELGLTD GSLVFLPFDT IHYALSPGPE ALAALANSSQ 310 320 330 340 350 360 LRRAHDAVLT LTRHCPSEGS VLDSLRRAQE RRELPSDLNL QQVSPLFGTI YDAVFLLARG 370 380 390 400 410 420 VAEARAAAGG RWVSGAAVAR HIRDAQVPGF CGDLGGDEEP PFVLLDTDAA GDRLFATYML 430 440 450 460 470 480 DPARGSFLSA GTRMHFPRGG SAPGPDPSCW FDPNNICGGG LEPGLVFLGF LLVVGMGLAG 490 500 510 520 530 540 AFLAHYVRHR LLHMQMVSGP NKIILTVDDI TFLHPHGGTS RKVAQGSRSS LGARSMSDIR 550 560 570 580 590 600 SGPSQHLDSP NIGVYEGDRV WLKKFPGDQH IAIRPATKTA FSKLQELRHE NVALYLGLFL 610 620 630 640 650 660 ARGAEGPAAL WEGNLAVVSE HCTRGSLQDL LAQREIKLDW MFKSSLLLDL IKGIRYLHHR 670 680 690 700 710 720 GVAHGRLKSR NCIVDGRFVL KITDHGHGRL LEAQKVLPEP PRAEDQLWTA PELLRDPALE 730 740 750 760 770 780 RRGTLAGDVF SLAIIMQEVV CRSAPYAMLE LTPEEVVQRV RSPPPLCRPL VSMDQAPVEC 790 800 810 820 830 840 ILLMKQCWAE QPELRPSMDH TFDLFKNINK GRKTNIIDSM LRMLEQYSSN LEDLIRERTE 850 860 870 880 890 900 ELELEKQKTD RLLTQMLPPS VAEALKTGTP VEPEYFEQVT LYFSDIVGFT TISAMSEPIE 910 920 930 940 950 960 VVDLLNDLYT LFDAIIGSHD VYKVETIGDA YMVASGLPQR NGQRHAAEIA NMSLDILSAV 970 980 990 1000 1010 1020 GTFRMRHMPE VPVRIRIGLH SGPCVAGVVG LTMPRYCLFG DTVNTASRME STGLPYRIHV 1030 1040 1050 1060 1070 1080 NLSTVGILRA LDSGYQVELR GRTELKGKGA EDTFWLVGRR GFNKPIPKPP DLQPGSSNHG 1090 1100 ISLQEIPPER RRKLEKARPG QFS

CATM prediction

The sequence of GUC2D_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  460       470       480       4
|    +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 GLEAGLVFLGFLLVVGMGLAGAFLAHYVRHR 6.6 -53.0° 1.9 45.2 -18.1
Model 2 GLEAGLVFLGFLLVVGMGLAGAFLAHYVRHR 7.0 -54.9° 1.5 45.2 -7.5
Model 3 GLEAGLVFLGFLLVVGMGLAGAFLAHYVRHR 7.3 -48.2° 0.7 54.1 -4.3
Prolines* GLEPGLVFLGFLLVVGMGLAGAFLAHYVRHR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 477, GLY, HA2 A, 476, MET, O 2.97Å
B, 480, GLY, HA1 A, 477, GLY, O 2.54Å
B, 481, ALA, HA A, 480, GLY, O 3.21Å
A, 477, GLY, HA2 B, 476, MET, O 2.97Å
A, 480, GLY, HA1 B, 477, GLY, O 2.54Å
A, 481, ALA, HA B, 480, GLY, O 3.21Å