Mucin-3A {ECO:0000305}

UniProt data

UniProt name: MUC3A_HUMAN (Q02505)

Gene name: MUC3A {ECO:0000312|HGNC:HGNC:7513}

Organism: Homo sapiens (Human).

Function: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. {ECO:0000269|PubMed:10405327}.

Subcellular location: Isoform 5: Secreted.

Transmembrane domains:

  1. 3227-3247, 21 AA, Helical. {ECO:0000255}.

Sequence: 3323 AA

10 20 30 40 50 60 MQLLGLLGLL WMLKASPWAT GTLSTATSIS QVPFPRAEAA SAVLSNSPHS RDLAGWPLGV 70 80 90 100 110 120 PQLASPAPGH RENAPMTLTT SPHDTLISET LLNSPVSSNT STTPTSKFAF KVETTPPTVL 130 140 150 160 170 180 VYSATTECVY PTSFIITISH PTSICVTTTQ VAFTSSYTST PVTQKPVTTV TSTYSMTTTE 190 200 210 220 230 240 KGTSAMTSSP STTTARETPI VTVTPSSVSA TDTTFHTTIS STTRTTERTP LPTGSIHTTT 250 260 270 280 290 300 SPTPVFTTLK TAVTSTSPIT SSITSTNTVT SMTTTASQPT ATNTLSSPTR TILSSTPVLS 310 320 330 340 350 360 TETITSGITN TTPLSTLVTT LPTTISRSTP TSETTYTTSP TSTVTDSTTK IAYSTSMTGT 370 380 390 400 410 420 LSTETSLPPT SSSLPTTETA TTPMTNLVTT TTEISSHSTP SFSSSTIYST VSTSTTAISS 430 440 450 460 470 480 LPPTSGTMVT STTMTPSSLS TDIPFTTPTT ITHHSVGSTG FLTTATDLTS TFTVSSSSAM 490 500 510 520 530 540 STSVIPSSPS IQNTETSSLV SMTSATTPNV RPTFVSTLST PTSSLLTTFP ATYSFSSSMS 550 560 570 580 590 600 ASSAGTTHTE SISSPPASTS TLHTTAESTL APTTTTSFTT STTMEPPSTT AATTGTGQTT 610 620 630 640 650 660 FTSSTATFPE TTTPTPTTDM STESLTTAMT SPPITSSVTS TNTVTSMTTT TSPPTTTNSF 670 680 690 700 710 720 TSLTSMPLSS TPVPSTEVVT SGTINTIPPS ILVTTLPTPN ASSMTTSETT YPNSPTGPGT 730 740 750 760 770 780 NSTTEITYPT TMTETSSTAT SLPPTSPLVS TAKTAKTPTT NLVTTTTKTT SHSTTSFTSS 790 800 810 820 830 840 TVYSTASTYT TAITSVPTTL GTMVTSTSMI SSTVSTGIPT SQPTTITPSS VGISGSLPMM 850 860 870 880 890 900 TDLTSVYTVS NMSARPTTVI PSSPTVQNTE ISISVSMTSA TTPSGGPTFT STENTPTRSL 910 920 930 940 950 960 LTSFPMTHSF SSSMSESSAG TTHTESISSP RGTTSTLHTT VESTPSPTTT TSFTTSTMME 970 980 990 1000 1010 1020 PPSSTVSTTG RGQTTFPSST ATFPETTTLT PTTDISTVSL TTAMTSPPPV SSSITPTNTM 1030 1040 1050 1060 1070 1080 TSMRTTTYWP TATNTLSPLT SSILSSTPVP STEMITSHTT NTTPLSTLVT TLLTTITRST 1090 1100 1110 1120 1130 1140 PTSETTYPTS PTSIVSDSTT EITYSTSITG TLSTATTLPP TSSSLPTTET ATMTPTTTLI 1150 1160 1170 1180 1190 1200 TTTPNTTSLS TPSFTSSTIY STVSTSTTAI SSASPTSGTM VTSTTMTPSS LSTDTPSTTP 1210 1220 1230 1240 1250 1260 TTITYPSVGS TGFLTTATDL TSTFTVSSSS AMSTSVIPSS PSIQNTETSS LVSMTSATTP 1270 1280 1290 1300 1310 1320 SLRPTITSTD STLTSSLLTT FPSTYSFSSS MSASSAGTTH TETISSLPAS TNTIHTTAES 1330 1340 1350 1360 1370 1380 ALAPTTTTSF TTSPTMEPPS TTVATTGTGQ TTFPSSTATF LETTTLTPTT DFSTESLTTA 1390 1400 1410 1420 1430 1440 MTSTPPITSS ITPTDTMTSM RTTTSWPTAT NTLSPLTSSI LSSTPVPSTE VTTSHTTNTN 1450 1460 1470 1480 1490 1500 PVSTLVTTLP ITITRSTLTS ETAYPSSPTS TVTESTTEIT YPTTMTETSS TATSLPPTSS 1510 1520 1530 1540 1550 1560 LVSTAETAKT PTTNLVTTTT KTTSHSTTSF TSSTIYSTAS TPTTAITSVP TTLGTMVTST 1570 1580 1590 1600 1610 1620 SMIPSTVSTG IPTSQPTTIT PSSVGISGSL PMMTDLTSVY TVSSMSARPT SVIPSSPTVQ 1630 1640 1650 1660 1670 1680 NTETSIFVSM MSATTPSGGP TFTSTENTPT RSLLTSFPVT HSFSSSMSAS SVGTTHTQSI 1690 1700 1710 1720 1730 1740 SSPPAITSTL HTTAESTPSP TTTMSFTTFT KMETPSSTVA TTGTGQTTFT SSTATSPKTT 1750 1760 1770 1780 1790 1800 TLTPTSDIST GSFKTAVSST PPITSSITST YTVTSMTTTT PLGPTATNTL PSFTSSVSSS 1810 1820 1830 1840 1850 1860 TPVPSTEAIT SGTTNTTPLS TLVTTFSNSD TSSTPTSETT YPTSLTSALT DSTTRTTYST 1870 1880 1890 1900 1910 1920 NMTGTLSTVT SLRPTSSSLL TTVTATVPTT NLVTTTTKIT SHSTPSFTSS IATTETPSHS 1930 1940 1950 1960 1970 1980 TPRFTSSITT TETPSHSTPR FTSSITNTKT TSHSSPSFTS SITTTETTSH NTPSLTSSIT 1990 2000 2010 2020 2030 2040 TTKTTSHSTP SYTSLITTTT TTSHSTPSFT SSITTTETTS HNTPSLTSSI TTTETTSHST 2050 2060 2070 2080 2090 2100 PSFTSSITTE TTSHSTPSFT SLITITEITS HSTLSYTTSI TTTETPSHST LSFTSSITTT 2110 2120 2130 2140 2150 2160 ETTSHSTPSF TSSITTSEMP SHSTPSFTSS ITTTENATHS TPNFTSSITT TETTSHSTPS 2170 2180 2190 2200 2210 2220 FTSLITTTET TSHRWGTTET TSYSTPSFTS SNTITETTSH STPSYITSIT TTETPSSSTP 2230 2240 2250 2260 2270 2280 SFSSSITTTE TTSHSTPGFT SSITTTETTS HSTPSFTSSI TTTETTSHDT PSFTSSITTS 2290 2300 2310 2320 2330 2340 ETPSHSTPSS TSLITTTKTT SHSTPSFTSS ITTTETTSHS AHSFTSSITT TETTSHNTRS 2350 2360 2370 2380 2390 2400 FTSSITTTET NSHSTTSFTS SITTTETTSH STPSFSSSIT TTETPLHSTP GLTSWVTTTK 2410 2420 2430 2440 2450 2460 TTSHITPGLT SSITTTETTS HSTPGFTSSI TTTETTSEST PSLSSSTIYS TVSTSTTAIT 2470 2480 2490 2500 2510 2520 SHFTTSETAV TPTPVTPSSL STDIPTTSLR TLTPSSVGTS TSLTTTTDFP SIPTDISTLP 2530 2540 2550 2560 2570 2580 TRTHIISSSP SIQSTETSSL VGTTSPTMST VRMTLRITEN TPISSFSTSI VVIPETPTQT 2590 2600 2610 2620 2630 2640 PPVLTSATGT QTSPAPTTVT FGSTDSSTST LHTLTPSTAL STIVSTSQVP IPSTHSSTLQ 2650 2660 2670 2680 2690 2700 TTPSTPSLQT SLTSTSEFTT ESFTRGSTST NAILTSFSTI IWSSTPTIIM SSSPSSASIT 2710 2720 2730 2740 2750 2760 PVFSTTIHSV PSSPYIFSTE NVGSASITGF PSLSSSATTS TSSTSSSLTT ALTEITPFSY 2770 2780 2790 2800 2810 2820 ISLPSTTPCP GTITITIVPA SPTDPCVEMD PSTEATSPPT TPLTVFPFTT EMVTCPTSIS 2830 2840 2850 2860 2870 2880 IQTTLTTYMD TSSMMPESES SISPNASSST GTGTVPTNTV FTSTRLPTSE TWLSNSSVIP 2890 2900 2910 2920 2930 2940 LPLPGVSTIP LTMKPSSSLP TILRTSSKST HPSPPTTRTS ETPVATTQTP TTLTSRRTTR 2950 2960 2970 2980 2990 3000 ITSQMTTQST LTTTAGTCDN GGTWEQGQCA CLPGFSGDRC QLQTRCQNGG QWDGLKCQCP 3010 3020 3030 3040 3050 3060 STFYGSSCEF AVEQVDLDVV ETEVGMEVSV DQQFSPDLND NTSQAYRDFN KTFWNQMQKI 3070 3080 3090 3100 3110 3120 FADMQGFTFK GVEILSLRNG SIVVDYLVLL EMPFSPQLES EYEQVKTTLK EGLQNASQDV 3130 3140 3150 3160 3170 3180 NSCQDSQTLC FKPDSIKVNN NSKTELTPAA ICRRAAPTGY EEFYFPLVEA TRLRCVTKCT 3190 3200 3210 3220 3230 3240 SGVDNAIDCH QGQCVLETSG PTCRCYSTDT HWFSGPRCEV AVHWRALVGG LTAGAALLVL 3250 3260 3270 3280 3290 3300 LLLALGVRAV RSGWWGGQRR GRSWDQDRKW FETWDEEVVG TFSNWGFEDD GTDKDTNFYV 3310 3320 ALENVDTTMK VHIKRPEMTS SSV

CATM prediction

The sequence of MUC3A_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          2450      2460     
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 WRALVGGLTAGAALLVLLLLALGVRAV 7.0 -28.0° 5.2 47.0 -31.2
Model 2 WRALVGGLTAGAALLVLLLLALGVRAV 6.9 -48.0° 0.0 38.0 -23.1
Model 3 WRALVGGLTAGAALLVLLLLALGVRAV 7.1 -43.0° 3.5 50.0 -22.9
Model 4 WRALVGGLTAGAALLVLLLLALGVRAV 6.7 -53.0° 3.1 34.0 -17.9
Model 5 WRALVGGLTAGAALLVLLLLALGVRAV 7.1 -42.9° -0.0 34.2 -1.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 2448, GLY, HA1 A, 2445, LEU, O 3.44Å
A, 2448, GLY, HA1 B, 2445, LEU, O 3.44Å