Desmoglein-1

UniProt data

UniProt name: DSG1_HUMAN (Q02413)

Gene name: DSG1; Synonyms=CDHF4

Organism: Homo sapiens (Human).

Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome.

Transmembrane domains:

  1. 549-569, 21 AA, Helical. {ECO:0000255}.

Sequence: 1049 AA

10 20 30 40 50 60 MDWSFFRVVA MLFIFLVVVE VNSEFRIQVR DYNTKNGTIK WHSIRRQKRE WIKFAAACRE 70 80 90 100 110 120 GEDNSKRNPI AKIHSDCAAN QQVTYRISGV GIDQPPYGIF VINQKTGEIN ITSIVDREVT 130 140 150 160 170 180 PFFIIYCRAL NSMGQDLERP LELRVRVLDI NDNPPVFSMA TFAGQIEENS NANTLVMILN 190 200 210 220 230 240 ATDADEPNNL NSKIAFKIIR QEPSDSPMFI INRNTGEIRT MNNFLDREQY GQYALAVRGS 250 260 270 280 290 300 DRDGGADGMS AECECNIKIL DVNDNIPYME QSSYTIEIQE NTLNSNLLEI RVIDLDEEFS 310 320 330 340 350 360 ANWMAVIFFI SGNEGNWFEI EMNERTNVGI LKVVKPLDYE AMQSLQLSIG VRNKAEFHHS 370 380 390 400 410 420 IMSQYKLKAS AISVTVLNVI EGPVFRPGSK TYVVTGNMGS NDKVGDFVAT DLDTGRPSTT 430 440 450 460 470 480 VRYVMGNNPA DLLAVDSRTG KLTLKNKVTK EQYNMLGGKY QGTILSIDDN LQRTCTGTIN 490 500 510 520 530 540 INIQSFGNDD RTNTEPNTKI TTNTGRQEST SSTNYDTSTT STDSSQVYSS EPGNGAKDLL 550 560 570 580 590 600 SDNVHFGPAG IGLLIMGFLV LGLVPFLMIC CDCGGAPRSA AGFEPVPECS DGAIHSWAVE 610 620 630 640 650 660 GPQPEPRDIT TVIPQIPPDN ANIIECIDNS GVYTNEYGGR EMQDLGGGER MTGFELTEGV 670 680 690 700 710 720 KTSGMPEICQ EYSGTLRRNS MRECREGGLN MNFMESYFCQ KAYAYADEDE GRPSNDCLLI 730 740 750 760 770 780 YDIEGVGSPA GSVGCCSFIG EDLDDSFLDT LGPKFKKLAD ISLGKESYPD LDPSWPPQST 790 800 810 820 830 840 EPVCLPQETE PVVSGHPPIS PHFGTTTVIS ESTYPSGPGV LHPKPILDPL GYGNVTVTES 850 860 870 880 890 900 YTTSDTLKPS VHVHDNRPAS NVVVTERVVG PISGADLHGM LEMPDLRDGS NVIVTERVIA 910 920 930 940 950 960 PSSSLPTSLT IHHPRESSNV VVTERVIQPT SGMIGSLSMH PELANAHNVI VTERVVSGAG 970 980 990 1000 1010 1020 VTGISGTTGI SGGIGSSGLV GTSMGAGSGA LSGAGISGGG IGLSSLGGTA SIGHMRSSSD 1030 1040 HHFNQTIGSA SPSTARSRIT KYSTVQYSK

CATM prediction

The sequence of DSG1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      550       560       570
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 FGAAGIGLLIMGFLVLGLVAFLMICCD 6.7 -40.1° 4.1 38.0 -24.8
Prolines* FGPAGIGLLIMGFLVLGLVPFLMICCD          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 552, GLY, HA1 A, 549, ALA, O 2.82Å
B, 553, LEU, HA A, 552, GLY, O 3.49Å
A, 552, GLY, HA1 B, 549, ALA, O 2.82Å
A, 553, LEU, HA B, 552, GLY, O 3.49Å