Dihydroorotate dehydrogenase (quinone), mitochondrial

UniProt data

UniProt name: PYRD_HUMAN (Q02127)

Gene name: DHODH

Organism: Homo sapiens (Human).

Function: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:10727948}; Single-pass membrane protein {ECO:0000269|PubMed:10727948}.

Transmembrane domains:

  1. 11-30, 20 AA, Helical. {ECO:0000250}.

Sequence: 395 AA

10 20 30 40 50 60 MAWRHLKKRA QDAVIILGGG GLLFASYLMA TGDERFYAEH LMPTLQGLLD PESAHRLAVR 70 80 90 100 110 120 FTSLGLLPRA RFQDSDMLEV RVLGHKFRNP VGIAAGFDKH GEAVDGLYKM GFGFVEIGSV 130 140 150 160 170 180 TPKPQEGNPR PRVFRLPEDQ AVINRYGFNS HGLSVVEHRL RARQQKQAKL TEDGLPLGVN 190 200 210 220 230 240 LGKNKTSVDA AEDYAEGVRV LGPLADYLVV NVSSPNTAGL RSLQGKAELR RLLTKVLQER 250 260 270 280 290 300 DGLRRVHRPA VLVKIAPDLT SQDKEDIASV VKELGIDGLI VTNTTVSRPA GLQGALRSET 310 320 330 340 350 360 GGLSGKPLRD LSTQTIREMY ALTQGRVPII GVGGVSSGQD ALEKIRAGAS LVQLYTALTF 370 380 390 WGPPVVGKVK RELEALLKEQ GFGGVTDAIG ADHRR

CATM prediction

The sequence of PYRD_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    10        20        30  
  |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 KRAQDAVIILGGGGLLFASYLMATGD 7.2 -47.6° 0.0 37.8 -8.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 20, GLY, HA1 A, 17, LEU, O 3.40Å
B, 21, GLY, HA2 A, 20, GLY, O 3.33Å
A, 20, GLY, HA1 B, 17, LEU, O 3.40Å
A, 21, GLY, HA2 B, 20, GLY, O 3.33Å