Interferon-induced transmembrane protein 2

UniProt data

UniProt name: IFM2_HUMAN (Q01629)

Gene name: IFITM2

Organism: Homo sapiens (Human).

Function: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 107-127, 21 AA, Helical. {ECO:0000255}.

Sequence: 132 AA

10 20 30 40 50 60 MNHIVQTFSP VNSGQPPNYE MLKEEQEVAM LGVPHNPAPP MSTVIHIRSE TSVPDHVVWS 70 80 90 100 110 120 LFNTLFMNTC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGIFMTILL 130 IIIPVLVVQA QR

CATM prediction

The sequence of IFM2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        110       120       1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 CLNIWALILGIFMTILLIIIAVLVVQA 7.4 -50.4° 3.3 48.0 -27.2
Prolines* CLNIWALILGIFMTILLIIIPVLVVQA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 110, LEU, HA A, 109, ALA, O 3.34Å
B, 113, GLY, HA1 A, 110, LEU, O 3.38Å
B, 114, ILE, HA A, 117, THR, OG1 2.87Å
A, 110, LEU, HA B, 109, ALA, O 3.34Å
A, 113, GLY, HA1 B, 110, LEU, O 3.38Å
A, 114, ILE, HA B, 117, THR, OG1 2.87Å