Ephrin-B1

UniProt data

UniProt name: EFNB1_HUMAN (P98172)

Gene name: EFNB1; Synonyms=EFL3, EPLG2, LERK2

Organism: Homo sapiens (Human).

Function: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 238-258, 21 AA, Helical. {ECO:0000255}.

Sequence: 346 AA

10 20 30 40 50 60 MARPGQRWLG KWLVAMVVWA LCRLATPLAK NLEPVSWSSL NPKFLSGKGL VIYPKIGDKL 70 80 90 100 110 120 DIICPRAEAG RPYEYYKLYL VRPEQAAACS TVLDPNVLVT CNRPEQEIRF TIKFQEFSPN 130 140 150 160 170 180 YMGLEFKKHH DYYITSTSNG SLEGLENREG GVCRTRTMKI IMKVGQDPNA VTPEQLTTSR 190 200 210 220 230 240 PSKEADNTVK MATQAPGSRG SLGDSDGKHE TVNQEEKSGP GASGGSSGDP DGFFNSKVAL 250 260 270 280 290 300 FAAVGAGCVI FLLIIIFLTV LLLKLRKRHR KHTQQRAAAL SLSTLASPKG GSGTAGTEPS 310 320 330 340 DIIIPLRTTE NNYCPHYEKV SGDYGHPVYI VQEMPPQSPA NIYYKV

CATM prediction

The sequence of EFNB1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       240       250       26
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 NSKVALFAAVGAGCVIFLLIIIFLTVL 7.0 -50.9° 2.4 45.1 -37.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 244, VAL, HA A, 243, ALA, O 3.18Å
B, 247, GLY, HA1 A, 244, VAL, O 2.98Å
A, 244, VAL, HA B, 243, ALA, O 3.18Å
A, 247, GLY, HA1 B, 244, VAL, O 2.98Å