Very low-density lipoprotein receptor

UniProt data

UniProt name: VLDLR_HUMAN (P98155)

Gene name: VLDLR

Organism: Homo sapiens (Human).

Function: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.

Transmembrane domains:

  1. 798-819, 22 AA, Helical. {ECO:0000255}.

Sequence: 873 AA

10 20 30 40 50 60 MGTSALWALW LLLALCWAPR ESGATGTGRK AKCEPSQFQC TNGRCITLLW KCDGDEDCVD 70 80 90 100 110 120 GSDEKNCVKK TCAESDFVCN NGQCVPSRWK CDGDPDCEDG SDESPEQCHM RTCRIHEISC 130 140 150 160 170 180 GAHSTQCIPV SWRCDGENDC DSGEDEENCG NITCSPDEFT CSSGRCISRN FVCNGQDDCS 190 200 210 220 230 240 DGSDELDCAP PTCGAHEFQC STSSCIPISW VCDDDADCSD QSDESLEQCG RQPVIHTKCP 250 260 270 280 290 300 ASEIQCGSGE CIHKKWRCDG DPDCKDGSDE VNCPSRTCRP DQFECEDGSC IHGSRQCNGI 310 320 330 340 350 360 RDCVDGSDEV NCKNVNQCLG PGKFKCRSGE CIDISKVCNQ EQDCRDWSDE PLKECHINEC 370 380 390 400 410 420 LVNNGGCSHI CKDLVIGYEC DCAAGFELID RKTCGDIDEC QNPGICSQIC INLKGGYKCE 430 440 450 460 470 480 CSRGYQMDLA TGVCKAVGKE PSLIFTNRRD IRKIGLERKE YIQLVEQLRN TVALDADIAA 490 500 510 520 530 540 QKLFWADLSQ KAIFSASIDD KVGRHVKMID NVYNPAAIAV DWVYKTIYWT DAASKTISVA 550 560 570 580 590 600 TLDGTKRKFL FNSDLREPAS IAVDPLSGFV YWSDWGEPAK IEKAGMNGFD RRPLVTADIQ 610 620 630 640 650 660 WPNGITLDLI KSRLYWLDSK LHMLSSVDLN GQDRRIVLKS LEFLAHPLAL TIFEDRVYWI 670 680 690 700 710 720 DGENEAVYGA NKFTGSELAT LVNNLNDAQD IIVYHELVQP SGKNWCEEDM ENGGCEYLCL 730 740 750 760 770 780 PAPQINDHSP KYTCSCPSGY NVEENGRDCQ STATTVTYSE TKDTNTTEIS ATSGLVPGGI 790 800 810 820 830 840 NVTTAVSEVS VPPKGTSAAW AILPLLLLVM AAVGGYLMWR NWQHKNMKSM NFDNPVYLKT 850 860 870 TEEDLSIDIG RHSASVGHTY PAISVVSTDD DLA

CATM prediction

The sequence of VLDLR_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       800       810       820
+    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 GTSAAWAILALLLLVMAAVGGYLMWRNW 7.0 -45.7° 3.6 37.1 -12.3
Model 2 GTSAAWAILALLLLVMAAVGGYLMWRNW 6.9 -49.0° 1.8 44.9 -11.8
Prolines* GTSAAWAILPLLLLVMAAVGGYLMWRNW          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 812, ALA, HA A, 811, ALA, O 2.98Å
B, 815, GLY, HA1 A, 812, ALA, O 3.05Å
A, 812, ALA, HA B, 811, ALA, O 2.98Å
A, 815, GLY, HA1 B, 812, ALA, O 3.05Å