UniProt data
UniProt name: PHEX_HUMAN (P78562)
Gene name: PHEX; Synonyms=PEX
Organism: Homo sapiens (Human).
Function: Probably involved in bone and dentin mineralization and renal phosphate reabsorption.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Transmembrane domains:
- 21-41, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 749 AA
10 20 30 40 50 60
MEAETGSSVE TGKKANRGTR IALVVFVGGT LVLGTILFLV SQGLLSLQAK QEYCLKPECI
70 80 90 100 110 120
EAAAAILSKV NLSVDPCDNF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKELLE
130 140 150 160 170 180
KSISRRRDTE AIQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL ESNIGPEGVW
190 200 210 220 230 240
SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDYLDNST
250 260 270 280 290 300
EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM
310 320 330 340 350 360
NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDISPSENVV VRVPQYFKDL FRILGSERKK
370 380 390 400 410 420
TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK
430 440 450 460 470 480
MFVDVYFQED KKEMMEELVE GVRWAFIDML EKENEWMDAG TKRKAKEKAR AVLAKVGYPE
490 500 510 520 530 540
FIMNDTHVNE DLKAIKFSEA DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF
550 560 570 580 590 600
YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD
610 620 630 640 650 660
PWWSTESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW
670 680 690 700 710 720
INDRRQGLEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA AREQVQIGAH SPPQFRVNGA
730 740
ISNFEEFQKA FNCPPNSTMN RGMDSCRLW
CATM prediction
The sequence of PHEX_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 20 30 40 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | GTRIALVVFVGGTLVLGTILFLVSQGL | 7.1 | -55.0° | 2.4 | 47.9 | -15.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 31, LEU, HA | A, 30, THR, O | 3.30Å |
| B, 34, GLY, HA1 | A, 31, LEU, O | 3.04Å |
| A, 31, LEU, HA | B, 30, THR, O | 3.30Å |
| A, 34, GLY, HA1 | B, 31, LEU, O | 3.04Å |