Interleukin-13 receptor subunit alpha-1

UniProt data

UniProt name: I13R1_HUMAN (P78552)

Gene name: IL13RA1; Synonyms=IL13R, IL13RA

Organism: Homo sapiens (Human).

Function: Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 344-367, 24 AA, Helical. {ECO:0000255}.

Sequence: 427 AA

10 20 30 40 50 60 MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW TWNPPEGASS 70 80 90 100 110 120 NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS QCSTNESEKP SILVEKCISP 130 140 150 160 170 180 PEGDPESAVT ELQCIWHNLS YMKCSWLPGR NTSPDTNYTL YYWHRSLEKI HQCENIFREG 190 200 210 220 230 240 QYFGCSFDLT KVKDSSFEQH SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN 250 260 270 280 290 300 DDLYVQWENP QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP 310 320 330 340 350 360 GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL IVPVIVAGAI 370 380 390 400 410 420 IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK KYDIYEKQTK EETDSVVLIE NLKKASQ

CATM prediction

The sequence of I13R1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           350       360       3
    +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 NSTLYITMLLIVAVIVAGAIIVLLLYLKRL 7.3 -54.8° 2.4 48.1 -5.0
Prolines* NSTLYITMLLIVPVIVAGAIIVLLLYLKRL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 355, ILE, HA A, 354, VAL, O 3.46Å
B, 358, GLY, HA1 A, 355, ILE, O 3.23Å
B, 366, TYR, HH A, 366, TYR, OH 2.14Å
A, 355, ILE, HA B, 354, VAL, O 3.46Å
A, 358, GLY, HA1 B, 355, ILE, O 3.23Å