Fractalkine

UniProt data

UniProt name: X3CL1_HUMAN (P78423)

Gene name: CX3CL1; Synonyms=FKN, NTT, SCYD1; ORFNames=A-152E5.2

Organism: Homo sapiens (Human).

Function: Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). {ECO:0000269|PubMed:21829356, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:9024663, ECO:0000269|PubMed:9177350, ECO:0000269|PubMed:9931005}.

Subcellular location: Processed fractalkine: Secreted {ECO:0000269|PubMed:9024663}.

Transmembrane domains:

  1. 342-362, 21 AA, Helical. {ECO:0000255}.

Sequence: 397 AA

10 20 30 40 50 60 MAPISLSWLL RLATFCHLTV LLAGQHHGVT KCNITCSKMT SKIPVALLIH YQQNQASCGK 70 80 90 100 110 120 RAIILETRQH RLFCADPKEQ WVKDAMQHLD RQAAALTRNG GTFEKQIGEV KPRTTPAAGG 130 140 150 160 170 180 MDESVVLEPE ATGESSSLEP TPSSQEAQRA LGTSPELPTG VTGSSGTRLP PTPKAQDGGP 190 200 210 220 230 240 VGTELFRVPP VSTAATWQSS APHQPGPSLW AEAKTSEAPS TQDPSTQAST ASSPAPEENA 250 260 270 280 290 300 PSEGQRVWGQ GQSPRPENSL EREEMGPVPA HTDAFQDWGP GSMAHVSVVP VSSEGTPSRE 310 320 330 340 350 360 PVASGSWTPK AEEPIHATMD PQRLGVLITP VPDAQAATRR QAVGLLAFLG LLFCLGVAMF 370 380 390 TYQSLQGCPR KMAGEMAEGL RYIPRSCGSN SYVLVPV

CATM prediction

The sequence of X3CL1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   340       350       360   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 RRQAVGLLAFLGLLFCLGVAMFTYQSL 7.3 -55.0° 4.2 38.0 -1.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session