Butyrophilin subfamily 3 member A2

UniProt data

UniProt name: BT3A2_HUMAN (P78410)

Gene name: BTN3A2; Synonyms=BT3.2, BTF3, BTF4

Organism: Homo sapiens (Human).

Function: Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}; Single-pass type I membrane protein {ECO:0000269|PubMed:21918970, ECO:0000269|PubMed:22767497}.

Transmembrane domains:

  1. 249-269, 21 AA, Helical. {ECO:0000255}.

Sequence: 334 AA

10 20 30 40 50 60 MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 70 80 90 100 110 120 ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 130 140 150 160 170 180 SGKYLCYFQD GDFYEKALVE LKVAALGSNL HVEVKGYEDG GIHLECRSTG WYPQPQIQWS 190 200 210 220 230 240 NAKGENIPAV EAPVVADGVG LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP 250 260 270 280 290 300 FFRSAQPWIA ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER 310 320 330 EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA

CATM prediction

The sequence of BT3A2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      250       260       270
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 QAWIAALAGTLAILLLLLAGASYFLWR 7.1 -46.1° 4.7 38.2 -13.1
Prolines* QPWIAALAGTLPILLLLLAGASYFLWR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 251, ALA, HA A, 250, ALA, O 2.97Å
B, 254, GLY, HA1 A, 251, ALA, O 3.30Å
A, 251, ALA, HA B, 250, ALA, O 2.97Å
A, 254, GLY, HA1 B, 251, ALA, O 3.30Å