Contactin-associated protein 1

UniProt data

UniProt name: CNTP1_HUMAN (P78357)

Gene name: CNTNAP1; Synonyms=CASPR, NRXN4

Organism: Homo sapiens (Human).

Function: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1284-1304, 21 AA, Helical. {ECO:0000255}.

Sequence: 1384 AA

10 20 30 40 50 60 MMHLRLFCIL LAAVSGAEGW GYYGCDEELV GPLYARSLGA SSYYSLLTAP RFARLHGISG 70 80 90 100 110 120 WSPRIGDPNP WLQIDLMKKH RIRAVATQGS FNSWDWVTRY MLLYGDRVDS WTPFYQRGHN 130 140 150 160 170 180 STFFGNVNES AVVRHDLHFH FTARYIRIVP LAWNPRGKIG LRLGLYGCPY KADILYFDGD 190 200 210 220 230 240 DAISYRFPRG VSRSLWDVFA FSFKTEEKDG LLLHAEGAQG DYVTLELEGA HLLLHMSLGS 250 260 270 280 290 300 SPIQPRPGHT TVSAGGVLND QHWHYVRVDR FGRDVNFTLD GYVQRFILNG DFERLNLDTE 310 320 330 340 350 360 MFIGGLVGAA RKNLAYRHNF RGCIENVIFN RVNIADLAVR RHSRITFEGK VAFRCLDPVP 370 380 390 400 410 420 HPINFGGPHN FVQVPGFPRR GRLAVSFRFR TWDLTGLLLF SRLGDGLGHV ELTLSEGQVN 430 440 450 460 470 480 VSIAQSGRKK LQFAAGYRLN DGFWHEVNFV AQENHAVISI DDVEGAEVRV SYPLLIRTGT 490 500 510 520 530 540 SYFFGGCPKP ASRWDCHSNQ TAFHGCMELL KVDGQLVNLT LVEGRRLGFY AEVLFDTCGI 550 560 570 580 590 600 TDRCSPNMCE HDGRCYQSWD DFICYCELTG YKGETCHTPL YKESCEAYRL SGKTSGNFTI 610 620 630 640 650 660 DPDGSGPLKP FVVYCDIREN RAWTVVRHDR LWTTRVTGSS MERPFLGAIQ YWNASWEEVS 670 680 690 700 710 720 ALANASQHCE QWIEFSCYNS RLLNTAGGYP YSFWIGRNEE QHFYWGGSQP GIQRCACGLD 730 740 750 760 770 780 RSCVDPALYC NCDADQPQWR TDKGLLTFVD HLPVTQVVIG DTNRSTSEAQ FFLRPLRCYG 790 800 810 820 830 840 DRNSWNTISF HTGAALRFPP IRANHSLDVS FYFRTSAPSG VFLENMGGPY CQWRRPYVRV 850 860 870 880 890 900 ELNTSRDVVF AFDVGNGDEN LTVHSDDFEF NDDEWHLVRA EINVKQARLR VDHRPWVLRP 910 920 930 940 950 960 MPLQTYIWME YDQPLYVGSA ELKRRPFVGC LRAMRLNGVT LNLEGRANAS EGTSPNCTGH 970 980 990 1000 1010 1020 CAHPRLPCFH GGRCVERYSY YTCDCDLTAF DGPYCNHDIG GFFEPGTWMR YNLQSALRSA 1030 1040 1050 1060 1070 1080 AREFSHMLSR PVPGYEPGYI PGYDTPGYVP GYHGPGYRLP DYPRPGRPVP GYRGPVYNVT 1090 1100 1110 1120 1130 1140 GEEVSFSFST SSAPAVLLYV SSFVRDYMAV LIKDDGTLQL RYQLGTSPYV YQLTTRPVTD 1150 1160 1170 1180 1190 1200 GQPHSINITR VYRNLFIQVD YFPLTEQKFS LLVDSQLDSP KALYLGRVME TGVIDPEIQR 1210 1220 1230 1240 1250 1260 YNTPGFSGCL SGVRFNNVAP LKTHFRTPRP MTAELAEALR VQGELSESNC GAMPRLVSEV 1270 1280 1290 1300 1310 1320 PPELDPWYLP PDFPYYHDEG WVAILLGFLV AFLLLGLVGM LVLFYLQNHR YKGSYHTNEP 1330 1340 1350 1360 1370 1380 KAAHEYHPGS KPPLPTSGPA QVPTPTAAPN QAPASAPAPA PTPAPAPGPR DQNLPQILEE SRSE

CATM prediction

The sequence of CNTP1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           1290      1300    
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 WVAILLGFLVAFLLLGLVGMLVLFYLQ 7.3 -53.2° 3.2 33.9 -24.2
Model 2 WVAILLGFLVAFLLLGLVGMLVLFYLQ 7.2 -50.0° 2.9 47.0 -19.3
Model 3 WVAILLGFLVAFLLLGLVGMLVLFYLQ 7.4 -41.1° 3.5 38.0 -12.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1296, GLY, HA2 A, 1295, LEU, O 3.50Å
B, 1299, GLY, HA1 A, 1296, GLY, O 3.37Å
A, 1296, GLY, HA2 B, 1295, LEU, O 3.50Å
A, 1299, GLY, HA1 B, 1296, GLY, O 3.37Å