Tyrosine-protein phosphatase non-receptor type substrate 1

UniProt data

UniProt name: SHPS1_HUMAN (P78324)

Gene name: SIRPA; Synonyms=BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP

Organism: Homo sapiens (Human).

Function: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. {ECO:0000250, ECO:0000269|PubMed:10469599, ECO:0000269|PubMed:11509594}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 374-394, 21 AA, Helical. {ECO:0000255}.

Sequence: 504 AA

10 20 30 40 50 60 MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET ATLRCTATSL 70 80 90 100 110 120 IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY 130 140 150 160 170 180 CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI 190 200 210 220 230 240 TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL 250 260 270 280 290 300 RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS 310 320 330 340 350 360 TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT 370 380 390 400 410 420 AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK AQGSTSSTRL HEPEKNAREI 430 440 450 460 470 480 TQDTNDITYA DLNLPKGKKP APQAAEPNNH TEYASIQTSP QPASEDTLTY ADLDMVHLNR 490 500 TPKQPAPKPE PSFSEYASVQ VPRK

CATM prediction

The sequence of SHPS1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           380       390     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 NIYIVVGVVCTLLVALLMAALYLVRIR 7.3 -50.5° 3.3 48.0 -10.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 377, GLY, HA1 A, 374, ILE, O 3.28Å
B, 378, VAL, HA A, 381, THR, OG1 2.83Å
A, 377, GLY, HA1 B, 374, ILE, O 3.28Å
A, 378, VAL, HA B, 381, THR, OG1 2.83Å