Coxsackievirus and adenovirus receptor

UniProt data

UniProt name: CXAR_HUMAN (P78310)

Gene name: CXADR; Synonyms=CAR

Organism: Homo sapiens (Human).

Function: (Microbial infection) Acts as a receptor for adenovirus type C (PubMed:9733828, PubMed:10666333, PubMed:12297051, PubMed:10567268). Acts as a receptor for Coxsackievirus B1 to B6 (PubMed:14978041, PubMed:10814575). {ECO:0000269|PubMed:10567268, ECO:0000269|PubMed:10666333, ECO:0000269|PubMed:10814575, ECO:0000269|PubMed:12297051, ECO:0000269|PubMed:14978041, ECO:0000269|PubMed:9733828}.

Subcellular location: Isoform 5: Secreted {ECO:0000269|PubMed:14978041}.

Transmembrane domains:

  1. 238-258, 21 AA, Helical. {ECO:0000255}.

Sequence: 365 AA

10 20 30 40 50 60 MALLLCFVLL CGVVDFARSL SITTPEEMIE KAKGETAYLP CKFTLSPEDQ GPLDIEWLIS 70 80 90 100 110 120 PADNQKVDQV IILYSGDKIY DDYYPDLKGR VHFTSNDLKS GDASINVTNL QLSDIGTYQC 130 140 150 160 170 180 KVKKAPGVAN KKIHLVVLVK PSGARCYVDG SEEIGSDFKI KCEPKEGSLP LQYEWQKLSD 190 200 210 220 230 240 SQKMPTSWLA EMTSSVISVK NASSEYSGTY SCTVRNRVGS DQCLLRLNVV PPSNKAGLIA 250 260 270 280 290 300 GAIIGTLLAL ALIGLIIFCC RKKRREEKYE KEVHHDIRED VPPPKSRTST ARSYIGSNHS 310 320 330 340 350 360 SLGSMSPSNM EGYSKTQYNQ VPSEDFERTP QSPTLPPAKV AAPNLSRMGA IPVMIPAQSK DGSIV

CATM prediction

The sequence of CXAR_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       240       250       26
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 KAGLIAGAIIGTLLALALIGLIIFCCR 6.6 -28.0° 3.2 47.9 -39.6
Model 2 KAGLIAGAIIGTLLALALIGLIIFCCR 6.5 -43.6° 5.0 43.9 -37.3
Model 3 KAGLIAGAIIGTLLALALIGLIIFCCR 6.4 -42.8° 2.3 61.9 -24.8
Model 4 KAGLIAGAIIGTLLALALIGLIIFCCR 7.0 -46.1° 2.3 32.1 -6.3
Model 5 KAGLIAGAIIGTLLALALIGLIIFCCR 6.7 -55.0° 3.6 63.0 -5.2
Model 6 KAGLIAGAIIGTLLALALIGLIIFCCR 7.3 -51.0° 0.1 45.1 -2.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 241, GLY, HA1 A, 238, LEU, O 2.79Å
B, 242, ALA, HA A, 241, GLY, O 2.96Å
A, 241, GLY, HA1 B, 238, LEU, O 2.79Å
A, 242, ALA, HA B, 241, GLY, O 2.96Å