Nodal modulator 3

UniProt data

UniProt name: NOMO3_HUMAN (P69849)

Gene name: NOMO3

Organism: Homo sapiens (Human).

Function: May antagonize Nodal signaling. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1156-1176, 21 AA, Helical. {ECO:0000255}.

Sequence: 1222 AA

10 20 30 40 50 60 MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN YSLIEIKLYT 70 80 90 100 110 120 KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF EPTTVELHVD GVSDICTKGG 130 140 150 160 170 180 DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD 190 200 210 220 230 240 YEILATHPTW ALKEASTTVR VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS 250 260 270 280 290 300 LVTKEDVLGC NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI 310 320 330 340 350 360 TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT LNNQIKVKTK 370 380 390 400 410 420 ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL ADIVATGFSV CGQISIIRFP 430 440 450 460 470 480 DTVKQMNKYK VVLSSQDKDK SLVTVETDAH GSFCFKANPG TYKVQVMVPE AETRAGLTLK 490 500 510 520 530 540 PQTFPLTVTD RPVMDVAFVQ FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV 550 560 570 580 590 600 NAMTFTFDNV LPGKYKISIM HEDWCWKNKS LEVEVLEDDV SAVEFRQTGY MLRCSLSHAI 610 620 630 640 650 660 TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT YDTSSPSILT 670 680 690 700 710 720 LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK SVQELRREQQ LAEIEARRQE 730 740 750 760 770 780 REKNGNEEGE ERMTKPPVQE MVDELQGPFS YDFSYWARSG EKITVTPSSK ELLFYPPSME 790 800 810 820 830 840 AVVSGESCPG KLIEIHGKAG LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV 850 860 870 880 890 900 GPLHSDLEYT VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG 910 920 930 940 950 960 LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL KITITGYRTA 970 980 990 1000 1010 1020 YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE GKFRLRGLLP GCVYHVQLKA 1030 1040 1050 1060 1070 1080 EGNDHIERAL PHHRVIEVGN NDIDDVNIIV FRQINQFDLS GNVITSSEYL PTLWVKLYKS 1090 1100 1110 1120 1130 1140 ENLDNPIQTV SLGQSLFFHF PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH 1150 1160 1170 1180 1190 1200 ITLIFNPTRK LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVGALGQA 1210 1220 ASDNSGPEDA KRQAKKQKTR RT

CATM prediction

The sequence of NOMO3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         1160      1170      
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 EQDIAQGSYIALALTLLVLLAGYNHDK 6.9 -47.0° 1.4 45.1 -14.3
Prolines* EQDIAQGSYIALPLTLLVLLAGYNHDK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1159, GLY, HA1 A, 1156, ILE, O 2.88Å
B, 1160, SER, HA A, 1159, GLY, O 3.13Å
A, 1159, GLY, HA1 B, 1156, ILE, O 2.88Å
A, 1160, SER, HA B, 1159, GLY, O 3.13Å