Signal peptidase complex catalytic subunit SEC11A

UniProt data

UniProt name: SC11A_HUMAN (P67812)

Gene name: SEC11A; Synonyms=SEC11L1, SPC18, SPCS4A

Organism: Homo sapiens (Human).

Function: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.

Subcellular location: Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 17-36, 20 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 179 AA

10 20 30 40 50 60 MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM VITGSESPIV VVLSGSMEPA 70 80 90 100 110 120 FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK IHEKQNGHIK FLTKGDNNAV 130 140 150 160 170 DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG IVTILMNDYP KFKYAVLFLL GLFVLVHRE

CATM prediction

The sequence of SC11A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        20        30        
 +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 NKRQLYYQVLNFGMIVSSALMIWKGL 7.2 -44.1° 1.8 45.0 -17.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 23, LEU, HA A, 22, VAL, O 3.35Å
B, 26, GLY, HA1 A, 23, LEU, O 3.14Å
B, 27, MET, HA A, 26, GLY, O 3.46Å
B, 30, SER, HG1 A, 27, MET, O 2.50Å
A, 23, LEU, HA B, 22, VAL, O 3.35Å
A, 26, GLY, HA1 B, 23, LEU, O 3.14Å
A, 27, MET, HA B, 26, GLY, O 3.46Å
A, 30, SER, HG1 B, 27, MET, O 2.50Å