Vesicle-associated membrane protein 2

UniProt data

UniProt name: VAMP2_HUMAN (P63027)

Gene name: VAMP2; Synonyms=SYB2

Organism: Homo sapiens (Human).

Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63045}.

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane {ECO:0000250|UniProtKB:P63045}. Note=Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651). {ECO:0000269|PubMed:17313651}.

Transmembrane domains:

  1. 95-114, 20 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 116 AA

10 20 30 40 50 60 MSATAATAPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL 70 80 90 100 110 SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IVYFST

CATM prediction

The sequence of VAMP2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          100       110    
   +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 NLKMMIILGVICAIILIIIIVYFST 7.2 -46.7° 1.4 44.7 -14.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 97, ILE, HA A, 96, MET, O 3.48Å
B, 100, GLY, HA1 A, 97, ILE, O 3.09Å
B, 101, VAL, HA A, 100, GLY, O 3.27Å
A, 97, ILE, HA B, 96, MET, O 3.48Å
A, 100, GLY, HA1 B, 97, ILE, O 3.09Å
A, 101, VAL, HA B, 100, GLY, O 3.27Å