Endogenous retrovirus group S71 member 1 Env polyprotein

UniProt data

UniProt name: ENVT1_HUMAN (P61550)

Gene name: ERVS71-1

Organism: Homo sapiens (Human).

Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=At the origin, this retroviral envelope protein was localized in the virion. {ECO:0000305}.

Transmembrane domains:

  1. 576-596, 21 AA, Helical. {ECO:0000255}.

Sequence: 626 AA

10 20 30 40 50 60 MGPEAWVRPL KTAPKPGEAI RLILFIYLSC FFLPVMSSEP SYSFLLTSFT TGRVFANTTW 70 80 90 100 110 120 RAGTSKEVSF AVDLCVLFPE PARTHEEQHN LPVIGAGSVD LAAGFGHSGS QTGCGSSKGA 130 140 150 160 170 180 EKGLQNVDFY LCPGNHPDAS CRDTYQFFCP DWTCVTLATY SGGSTRSSTL SISRVPHPKL 190 200 210 220 230 240 CTRKNCNPLT ITVHDPNAAQ WYYGMSWGLR LYIPGFDVGT MFTIQKKILV SWSSPKPIGP 250 260 270 280 290 300 LTDLGDPIFQ KHPDKVDLTV PLPFLVPRPQ LQQQHLQPSL MSILGGVHHL LNLTQPKLAQ 310 320 330 340 350 360 DCWLCLKAKP PYYVGLGVEA TLKRGPLSCH TRPRALTIGD VSGNASCLIS TGYNLSASPF 370 380 390 400 410 420 QATCNQSLLT SISTSVSYQA PNNTWLACTS GLTRCINGTE PGPLLCVLVH VLPQVYVYSG 430 440 450 460 470 480 PEGRQLIAPP ELHPRLHQAV PLLVPLLAGL SIAGSAAIGT AALVQGETGL ISLSQQVDAD 490 500 510 520 530 540 FSNLQSAIDI LHSQVESLAE VVLQNCRCLD LLFLSQGGLC AALGESCCFY ANQSGVIKGT 550 560 570 580 590 600 VKKVRENLDR HQQERENNIP WYQSMFNWNP WLTTLITGLA GPLLILLLSL IFGPCILNSF 610 620 LNFIKQRIAS VKLTYLKTQY DTLVNN

CATM prediction

The sequence of ENVT1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         580       590       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 TTLITGLAGALLILLLSLIFGACILNS 7.5 -46.0° 2.7 47.0 -13.2
Model 2 TTLITGLAGALLILLLSLIFGACILNS 7.3 -43.0° 4.5 35.0 -9.4
Prolines* TTLITGLAGPLLILLLSLIFGPCILNS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session