Syntaxin-1B

UniProt data

UniProt name: STX1B_HUMAN (P61266)

Gene name: STX1B; Synonyms=STX1B1, STX1B2

Organism: Homo sapiens (Human).

Function: Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity). {ECO:0000250}.

Subcellular location: Isoform 2: Nucleus {ECO:0000269|PubMed:18691641}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18691641}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18691641}. Note=Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.

Transmembrane domains:

  1. 265-288, 24 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 288 AA

10 20 30 40 50 60 MKDRTQELRS AKDSDDEEEV VHVDRDHFMD EFFEQVEEIR GCIEKLSEDV EQVKKQHSAI 70 80 90 100 110 120 LAAPNPDEKT KQELEDLTAD IKKTANKVRS KLKAIEQSIE QEEGLNRSSA DLRIRKTQHS 130 140 150 160 170 180 TLSRKFVEVM TEYNATQSKY RDRCKDRIQR QLEITGRTTT NEELEDMLES GKLAIFTDDI 190 200 210 220 230 240 KMDSQMTKQA LNEIETRHNE IIKLETSIRE LHDMFVDMAM LVESQGEMID RIEYNVEHSV 250 260 270 280 DYVERAVSDT KKAVKYQSKA RRKKIMIIIC CVVLGVVLAS SIGGTLGL

CATM prediction

The sequence of STX1B_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          270       280      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 RKKIMIIICCVVLGVVLASSIGGTLGL 6.9 -51.8° 1.3 57.2 -25.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 272, VAL, HA A, 271, CYS, O 3.22Å
B, 275, GLY, HA1 A, 272, VAL, O 2.92Å
B, 276, VAL, HA A, 275, GLY, O 3.47Å
A, 272, VAL, HA B, 271, CYS, O 3.22Å
A, 275, GLY, HA1 B, 272, VAL, O 2.92Å
A, 276, VAL, HA B, 275, GLY, O 3.47Å