Signal peptidase complex subunit 3

UniProt data

UniProt name: SPCS3_HUMAN (P61009)

Gene name: SPCS3; Synonyms=SPC22; ORFNames=UNQ1841/PRO3567

Organism: Homo sapiens (Human).

Function: Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000269|PubMed:27499293}.

Subcellular location: Microsome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 12-32, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 180 AA

10 20 30 40 50 60 MNTVLSRANS LFAFSLSVMA ALTFGCFITT AFKDRSVPVR LHVSRIMLKN VEDFTGPRER 70 80 90 100 110 120 SDLGFITFDI TADLENIFDW NVKQLFLYLS AEYSTKNNAL NQVVLWDKIV LRGDNPKLLL 130 140 150 160 170 KDMKTKYFFF DDGNGLKGNR NVTLTLSWNV VPNAGILPLV TGSGHVSVPF PDTYEITKSY

CATM prediction

The sequence of SPCS3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   10        20        30    
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 NSLFAFSLSVMAALTFGCFITTAFKDR 7.0 -46.0° 2.7 47.1 -15.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 22, LEU, HA A, 21, ALA, O 2.99Å
B, 25, GLY, HA1 A, 22, LEU, O 2.96Å
B, 26, CYS, HA A, 29, THR, OG1 2.34Å
A, 22, LEU, HA B, 21, ALA, O 2.99Å
A, 25, GLY, HA1 B, 22, LEU, O 2.96Å
A, 26, CYS, HA B, 29, THR, OG1 2.34Å