Reactive oxygen species modulator 1

UniProt data

UniProt name: ROMO1_HUMAN (P60602)

Gene name: ROMO1; Synonyms=C20orf52

Organism: Homo sapiens (Human).

Function: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}; Single-pass membrane protein {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}.

Transmembrane domains:

  1. 22-44, 23 AA, Helical. {ECO:0000255}.

Sequence: 79 AA

10 20 30 40 50 60 MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR ELMGGIGKTM 70 MQSGGTFGTF MAIGMGIRC

CATM prediction

The sequence of ROMO1_HUMAN returned 21 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   20        30        40      
 |    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.7 -28.0° 2.4 50.3 -54.1
Model 2 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.4 -33.0° 4.6 49.2 -51.1
Model 3 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.0 -37.1° 0.3 44.5 -50.6
Model 4 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.7 -33.9° 6.0 61.1 -49.8
Model 5 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.7 -34.3° 4.0 62.4 -48.7
Model 6 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.4 -41.2° 0.6 42.9 -37.0
Model 7 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.5 -48.8° 4.5 48.8 -36.6
Model 8 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.5 -36.5° 4.3 48.1 -36.5
Model 9 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.4 -38.0° 5.0 58.8 -35.5
Model 10 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.9 -23.1° 4.2 54.0 -34.2
Model 11 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.2 -49.0° 2.8 32.4 -26.7
Model 12 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.2 -44.9° 4.1 38.8 -26.3
Model 13 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.5 -53.0° 4.2 53.5 -22.7
Model 14 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.1 -46.7° 2.3 45.0 -21.6
Model 15 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.0 -55.2° 2.4 48.2 -20.2
Model 16 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.4 -48.7° 4.5 48.9 -19.3
Model 17 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.7 -46.0° 6.0 59.0 -18.1
Model 18 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.2 -37.2° 2.2 36.2 -14.7
Model 19 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 6.5 -53.1° 5.3 57.7 -12.2
Model 20 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.0 +54.0° 3.3 79.9 -10.4
Model 21 VKMGFVMGCAVGMAAGALFGTFSCLRIGM 7.1 -53.0° 1.9 45.2 -7.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 23, PHE, HA A, 22, GLY, O 2.43Å
B, 26, GLY, HA1 A, 23, PHE, O 2.75Å
B, 27, CYS, HA A, 26, GLY, O 2.83Å
A, 23, PHE, HA B, 22, GLY, O 2.43Å
A, 26, GLY, HA1 B, 23, PHE, O 2.75Å
A, 27, CYS, HA B, 26, GLY, O 2.83Å