Endogenous retrovirus group PABLB member 1 Env polyprotein

UniProt data

UniProt name: ERB1_HUMAN (P60509)

Gene name: ERVPABLB-1

Organism: Homo sapiens (Human).

Function: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. {ECO:0000269|PubMed:14557543}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=At the origin, this retroviral envelope protein was localized in the virion. {ECO:0000305}.

Transmembrane domains:

  1. 452-472, 21 AA, Helical. {ECO:0000255}.

Sequence: 514 AA

10 20 30 40 50 60 MDPLHTIEKV PARRNIHDRG HQGHRMGDGT PGRPKISVQQ MTRFSLIIFF LSAPFVVNAS 70 80 90 100 110 120 TSNVFLQWAH SYADGLQQGD PCWVCGSLPV TNTMELPWWV SPLQGKDWVF FQSFIGDLKQ 130 140 150 160 170 180 WTGAQMTGVT RKNISEWPIN KTLNEPGHDK PFSVNETRDK VIAFAIPLLD TKVFVQTSRP 190 200 210 220 230 240 QNTQYRNGFL QIWDGFIWLT ATKGHLSQIA PLCWEQRNHS LDNWPNTTRV MGWIPPGQCR 250 260 270 280 290 300 HTILLQQRDL FATDWSQQPG LNWYAPNGTQ WLCSPNLWPW LPSGWLGCCT LGIPWAQGRW 310 320 330 340 350 360 VKTMEVYPYL PHVVNQGTRA IVHRNDHLPT IFMPSVGLGT VIQHIEALAN FTQRALNDSL 370 380 390 400 410 420 QSISLMNAEV YYMHEDILQN RMALDILTAA EGGTCALIKT ECCVYIPNNS RNISLALEDT 430 440 450 460 470 480 CRQIQVISSS ALSLHDWIAS QFSGRPSWWQ KILIVLATLW SVGIALCCGL YFCRMFSQHI 490 500 510 PQTHSIIFQQ ELPLSPPSQE HYQSQRDIFH SNAP

CATM prediction

The sequence of ERB1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   450       460       470   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 WQKILIVLATLWSVGIALCCGLYFCRM 6.9 -46.2° 2.7 47.2 -25.4
Model 2 WQKILIVLATLWSVGIALCCGLYFCRM 7.2 -54.9° 0.9 50.0 -15.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 466, LEU, HA A, 465, ALA, O 2.93Å
B, 469, GLY, HA1 A, 466, LEU, O 2.90Å
A, 466, LEU, HA B, 465, ALA, O 2.93Å
A, 469, GLY, HA1 B, 466, LEU, O 2.90Å