UniProt data
UniProt name: NRX2B_HUMAN (P58401)
Gene name: NRXN2
Organism: Homo sapiens (Human).
Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 591-611, 21 AA, Helical. {ECO:0000255}.
Sequence: 666 AA
10 20 30 40 50 60
MPPGGSGPGG CPRRPPALAG PLPPPPPPPP PPLLPLLPLL LLLLLGAAEG ARVSSSLSTT
70 80 90 100 110 120
HHVHHFHSKH GTVPIAINRM PFLTRGGHAG TTYIFGKGGA LITYTWPPND RPSTRMDRLA
130 140 150 160 170 180
VGFSTHQRSA VLVRVDSASG LGDYLQLHID QGTVGVIFNV GTDDITIDEP NAIVSDGKYH
190 200 210 220 230 240
VVRFTRSGGN ATLQVDSWPV NERYPAGNFD NERLAIARQR IPYRLGRVVD EWLLDKGRQL
250 260 270 280 290 300
TIFNSQAAIK IGGRDQGRPF QGQVSGLYYN GLKVLALAAE SDPNVRTEGH LRLVGEGPSV
310 320 330 340 350 360
LLSAETTATT LLADMATTIM ETTTTMATTT TRRGRSPTLR DSTTQNTDDL LVASAECPSD
370 380 390 400 410 420
DEDLEECEPS TGGELILPII TEDSLDPPPV ATRSPFVPPP PTFYPFLTGV GATQDTLPPP
430 440 450 460 470 480
AARRPPSGGP CQAERDDSDC EEPIEASGFA SGEVFDSSLP PTDDEDFYTT FPLVTDRTTL
490 500 510 520 530 540
LSPRKPAPRP NLRTDGATGA PGVLFAPSAP APNLPAGKMN HRDPLQPLLE NPPLGPGAPT
550 560 570 580 590 600
SFEPRRPPPL RPGVTSAPGF PHLPTANPTG PGERGPPGAV EVIRESSSTT GMVVGIVAAA
610 620 630 640 650 660
ALCILILLYA MYKYRNRDEG SYQVDQSRNY ISNSAQSNGA VVKEKAPAAP KTPSKAKKNK
DKEYYV
CATM prediction
The sequence of NRX2B_HUMAN returned 4 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 590 600 610 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | STTGMVVGIVAAAALCILILLYAMYKY | 6.4 | -47.1° | 3.3 | 54.0 | -30.3 |
| Model 2 | STTGMVVGIVAAAALCILILLYAMYKY | 7.3 | -27.0° | 6.0 | 58.0 | -24.3 |
| Model 3 | STTGMVVGIVAAAALCILILLYAMYKY | 7.3 | -37.0° | 2.2 | 36.0 | -19.9 |
| Model 4 | STTGMVVGIVAAAALCILILLYAMYKY | 6.6 | -54.8° | 5.8 | 46.9 | -12.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 592, MET, HA | A, 591, GLY, O | 2.41Å |
| B, 595, GLY, HA1 | A, 592, MET, O | 2.56Å |
| B, 596, ILE, HA | A, 595, GLY, O | 3.43Å |
| A, 592, MET, HA | B, 591, GLY, O | 2.41Å |
| A, 595, GLY, HA1 | B, 592, MET, O | 2.56Å |
| A, 596, ILE, HA | B, 595, GLY, O | 3.43Å |
