Neurexin-1-beta

UniProt data

UniProt name: NRX1B_HUMAN (P58400)

Gene name: NRXN1

Organism: Homo sapiens (Human).

Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Localized on the pre- synaptic membrane. {ECO:0000250}.

Transmembrane domains:

  1. 364-386, 23 AA, Helical. {ECO:0000255}.

Sequence: 442 AA

10 20 30 40 50 60 MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG ASSLGAHHIH 70 80 90 100 110 120 HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI TYKWPPNDRP STRADRLAIG 130 140 150 160 170 180 FSTVQKEAVL VRVDSSSGLG DYLELHIHQG KIGVKFNVGT DDIAIEESNA IINDGKYHVV 190 200 210 220 230 240 RFTRSGGNAT LQVDSWPVIE RYPAGRQLTI FNSQATIIIG GKEQGQPFQG QLSGLYYNGL 250 260 270 280 290 300 KVLNMAAEND ANIAIVGNVR LVGEVPSSMT TESTATAMQS EMSTSIMETT TTLATSTARR 310 320 330 340 350 360 GKPPTKEPIS QTTDDILVAS AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR 370 380 390 400 410 420 ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE 430 440 KQPSSAKSSN KNKKNKDKEY YV

CATM prediction

The sequence of NRX1B_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           370       380       
    +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 ESSSTTGMVVGIVAAAALCILILLYAMYK 6.5 -41.3° 0.6 42.6 -27.3
Model 2 ESSSTTGMVVGIVAAAALCILILLYAMYK 7.1 -23.2° 2.4 45.9 -26.4
Model 3 ESSSTTGMVVGIVAAAALCILILLYAMYK 7.2 -36.0° 3.6 36.0 -20.8
Model 4 ESSSTTGMVVGIVAAAALCILILLYAMYK 6.9 -36.0° 4.3 48.0 -8.2
Model 5 ESSSTTGMVVGIVAAAALCILILLYAMYK 7.1 -44.0° 4.9 44.2 -5.3
Model 6 ESSSTTGMVVGIVAAAALCILILLYAMYK 6.5 -52.8° 5.2 58.1 -3.6
Model 7 ESSSTTGMVVGIVAAAALCILILLYAMYK 7.2 -47.6° 3.3 33.8 -2.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 367, GLY, HA1 A, 364, SER, O 2.74Å
B, 368, MET, HA A, 367, GLY, O 2.42Å
B, 371, GLY, HA1 A, 368, MET, O 3.12Å
A, 367, GLY, HA1 B, 364, SER, O 2.74Å
A, 368, MET, HA B, 367, GLY, O 2.42Å
A, 371, GLY, HA1 B, 368, MET, O 3.12Å