Transmembrane protease serine 3

UniProt data

UniProt name: TMPS3_HUMAN (P57727)

Gene name: TMPRSS3; Synonyms=ECHOS1, TADG12; ORFNames=UNQ323/PRO382

Organism: Homo sapiens (Human).

Function: Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). {ECO:0000250, ECO:0000269|PubMed:12393794}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12393794}; Single-pass type II membrane protein {ECO:0000269|PubMed:12393794}.

Transmembrane domains:

  1. 49-69, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 454 AA

10 20 30 40 50 60 MGENDPPAVE APFSFRSLFG LDDLKISPVA PDADAVAAQI LSLLPLKFFP IIVIGIIALI 70 80 90 100 110 120 LALAIGLGIH FDCSGKYRCR SSFKCIELIA RCDGVSDCKD GEDEYRCVRV GGQNAVLQVF 130 140 150 160 170 180 TAASWKTMCS DDWKGHYANV ACAQLGFPSY VSSDNLRVSS LEGQFREEFV SIDHLLPDDK 190 200 210 220 230 240 VTALHHSVYV REGCASGHVV TLQCTACGHR RGYSSRIVGG NMSLLSQWPW QASLQFQGYH 250 260 270 280 290 300 LCGGSVITPL WIITAAHCVY DLYLPKSWTI QVGLVSLLDN PAPSHLVEKI VYHSKYKPKR 310 320 330 340 350 360 LGNDIALMKL AGPLTFNEMI QPVCLPNSEE NFPDGKVCWT SGWGATEDGA GDASPVLNHA 370 380 390 400 410 420 AVPLISNKIC NHRDVYGGII SPSMLCAGYL TGGVDSCQGD SGGPLVCQER RLWKLVGATS 430 440 450 FGIGCAEVNK PGVYTRVTSF LDWIHEQMER DLKT

CATM prediction

The sequence of TMPS3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      50        60        70 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LKFFAIIVIGIIALILALAIGLGIHFD 7.4 -45.0° 4.0 39.4 -8.2
Prolines* LKFFPIIVIGIIALILALAIGLGIHFD          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 63, LEU, HA A, 62, ALA, O 3.28Å
B, 66, GLY, HA1 A, 63, LEU, O 3.45Å
A, 63, LEU, HA B, 62, ALA, O 3.28Å
A, 66, GLY, HA1 B, 63, LEU, O 3.45Å