Junctional adhesion molecule B

UniProt data

UniProt name: JAM2_HUMAN (P57087)

Gene name: JAM2; Synonyms=C21orf43, VEJAM; ORFNames=UNQ219/PRO245

Organism: Homo sapiens (Human).

Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Subcellular location: Cell junction, tight junction {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.

Transmembrane domains:

  1. 239-259, 21 AA, Helical. {ECO:0000255}.

Sequence: 298 AA

10 20 30 40 50 60 MARRSRHRLL LLLLRYLVVA LGYHKAYGFS APKDQQVVTA VEYQEAILAC KTPKKTVSSR 70 80 90 100 110 120 LEWKKLGRSV SFVYYQQTLQ GDFKNRAEMI DFNIRIKNVT RSDAGKYRCE VSAPSEQGQN 130 140 150 160 170 180 LEEDTVTLEV LVAPAVPSCE VPSSALSGTV VELRCQDKEG NPAPEYTWFK DGIRLLENPR 190 200 210 220 230 240 LGSQSTNSSY TMNTKTGTLQ FNTVSKLDTG EYSCEARNSV GYRRCPGKRM QVDDLNISGI 250 260 270 280 290 IAAVVVVALV ISVCGLGVCY AQRKGYFSKE TSFQKSNSSS KATTMSENDF KHTKSFII

CATM prediction

The sequence of JAM2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      240       250       260
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 NISGIIAAVVVVALVISVCGLGVCYAQ 7.2 -46.9° 2.3 44.7 -1.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 252, SER, HA A, 251, ILE, O 3.40Å
B, 255, GLY, HA1 A, 252, SER, O 3.19Å
A, 252, SER, HA B, 251, ILE, O 3.40Å
A, 255, GLY, HA1 B, 252, SER, O 3.19Å