Pro-neuregulin-3, membrane-bound isoform

UniProt data

UniProt name: NRG3_HUMAN (P56975)

Gene name: NRG3

Organism: Homo sapiens (Human).

Function: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269|PubMed:16478787, ECO:0000269|PubMed:9275162}.

Subcellular location: Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.

Transmembrane domains:

  1. 361-381, 21 AA, Helical; Note=Internal signal sequence. {ECO:0000255}.

Sequence: 720 AA

10 20 30 40 50 60 MSEGAAAASP PGAASAAAAS AEEGTAAAAA AAAAGGGPDG GGEGAAEPPR ELRCSDCIVW 70 80 90 100 110 120 NRQQTWLCVV PLFIGFIGLG LSLMLLKWIV VGSVKEYVPT DLVDSKGMGQ DPFFLSKPSS 130 140 150 160 170 180 FPKAMETTTT TTSTTSPATP SAGGAASSRT PNRISTRLTT ITRAPTRFPG HRVPIRASPR 190 200 210 220 230 240 STTARNTAAP ATVPSTTAPF FSSSTLGSRP PVPGTPSTQA MPSWPTAAYA TSSYLHDSTP 250 260 270 280 290 300 SWTLSPFQDA ASSSSSSSSS ATTTTPETST SPKFHTTTYS TERSEHFKPC RDKDLAYCLN 310 320 330 340 350 360 DGECFVIETL TGSHKHCRCK EGYQGVRCDQ FLPKTDSILS DPTDHLGIEF MESEEVYQRQ 370 380 390 400 410 420 VLSISCIIFG IVIVGMFCAA FYFKSKKQAK QIQEQLKVPQ NGKSYSLKAS STMAKSENLV 430 440 450 460 470 480 KSHVQLQNYS KVERHPVTAL EKMMESSFVG PQSFPEVPSP DRGSQSVKHH RSLSSCCSPG 490 500 510 520 530 540 QRSGMLHRNA FRRTPPSPRS RLGGIVGPAY QQLEESRIPD QDTIPCQGIE VRKTISHLPI 550 560 570 580 590 600 QLWCVERPLD LKYSSSGLKT QRNTSINMQL PSRETNPYFN SLEQKDLVGY SSTRASSVPI 610 620 630 640 650 660 IPSVGLEETC LQMPGISEVK SIKWCKNSYS ADVVNVSIPV SDCLIAEQQE VKILLETVQE 670 680 690 700 710 QIRILTDARR SEDYELASVE TEDSASENTA FLPLSPTAKS EREAQFVLRN EIQRDSALTK

CATM prediction

The sequence of NRG3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    360       370       380  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 QRQVLSISCIIFGIVIVGMFCAAFYFK 7.2 -51.0° 1.2 44.9 -28.9
Model 2 QRQVLSISCIIFGIVIVGMFCAAFYFK 7.4 -51.0° 3.3 48.0 -5.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 375, GLY, HA1 A, 372, VAL, O 3.18Å
B, 376, MET, HA A, 375, GLY, O 3.35Å
A, 375, GLY, HA1 B, 372, VAL, O 3.18Å
A, 376, MET, HA B, 375, GLY, O 3.35Å