3-keto-steroid reductase

UniProt data

UniProt name: DHB7_HUMAN (P56937)

Gene name: HSD17B7; Synonyms=SDR37C1; ORFNames=UNQ2563/PRO6243

Organism: Homo sapiens (Human).

Function: Responsible for the reduction of the keto group on the C-3 of sterols. {ECO:0000269|PubMed:12829805}.

Subcellular location: Cell membrane; Single-pass membrane protein.

Transmembrane domains:

  1. 230-250, 21 AA, Helical. {ECO:0000255}.

Sequence: 341 AA

10 20 30 40 50 60 MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV 70 80 90 100 110 120 QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RKVIHMFSTA 130 140 150 160 170 180 EGLLTQGDKI TADGLQEVFE TNVFGHFILI RELEPLLCHS DNPSQLIWTS SRSARKSNFS 190 200 210 220 230 240 LEDFQHSKGK EPYSSSKYAT DLLSVALNRN FNQQGLYSNV ACPGTALTNL TYGILPPFIW 250 260 270 280 290 300 TLLMPAILLL RFFANAFTLT PYNGTEALVW LFHQKPESLN PLIKYLSATT GFGRNYIMTQ 310 320 330 340 KMDLDEDTAE KFYQKLLELE KHIRVTIQKT DNQARLSGSC L

CATM prediction

The sequence of DHB7_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     230       240       250 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 LTNLTYGILAAFIWTLLMAAILLLRFF 6.8 -40.0° 4.5 44.0 -25.9
Prolines* LTNLTYGILPPFIWTLLMPAILLLRFF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 233, GLY, HA1 A, 230, LEU, O 3.00Å
A, 233, GLY, HA1 B, 230, LEU, O 3.00Å