Beta-secretase 1

UniProt data

UniProt name: BACE1_HUMAN (P56817)

Gene name: BACE1; Synonyms=BACE, KIAA1149

Organism: Homo sapiens (Human).

Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. {ECO:0000269|PubMed:10677483, ECO:0000269|PubMed:20354142}.

Subcellular location: Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P56818}. Endoplasmic reticulum. Endosome {ECO:0000250|UniProtKB:P56818}. Cell surface. Cytoplasmic vesicle membrane. Membrane raft {ECO:0000250|UniProtKB:P56818}. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.

Transmembrane domains:

  1. 458-478, 21 AA, Helical. {ECO:0000255}.

Sequence: 501 AA

10 20 30 40 50 60 MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE PEEPGRRGSF 70 80 90 100 110 120 VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA VGAAPHPFLH RYYQRQLSST 130 140 150 160 170 180 YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL 190 200 210 220 230 240 GLAYAEIARP DDSLEPFFDS LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI 250 260 270 280 290 300 DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK 310 320 330 340 350 360 VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG EVTNQSFRIT 370 380 390 400 410 420 ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC 430 440 450 460 470 480 HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT DESTLMTIAY VMAAICALFM LPLCLMVCQW 490 500 CCLRCLRQQH DDFADDISLL K

CATM prediction

The sequence of BACE1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       460       470       48
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 LMTIAYVMAAICALFMLALCLMVCQWC 7.1 -33.2° 2.3 35.0 -4.3
Prolines* LMTIAYVMAAICALFMLPLCLMVCQWC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 460, TYR, HA A, 459, ALA, O 3.43Å
B, 463, ALA, HA A, 460, TYR, OH 3.11Å
A, 460, TYR, HA B, 459, ALA, O 3.43Å
A, 463, ALA, HA B, 460, TYR, OH 3.11Å